Comparison of effects of propofol and isosorbide dinitrateduring rewarming on cardiopulmonary bypass | Furqan | Pakistan Journal of Medical Sciences
 
مبل راحتی صندلی مدیریتی صندلی اداری میز اداری وبلاگدهی گن لاغری بازی اندروید تبلیغات کلیکی آموزش زبان انگلیسی پاراگلایدر مارکت اندروید تور آهنگ محسن چاوشی مسیح و آرش پروتز سینه پروتز باسن پروتز لب میز تلویزیون

Comparison of effects of propofol and isosorbide dinitrateduring rewarming on cardiopulmonary bypass

Aamir Furqan, Sohail Ahmad, Liaqat Ali, Rahat Akhtar, Mirza Ahmad Raza Baig, Rana Altaf

Abstract


Objectives: Comparison of effects of propofol and isosorbide dinitrate during rewarming on cardiopulmonary bypass in patients undergoing coronary artery bypasses grafting.

Methods: It was randomized prospective clinical trial. One hundred and twenty patient (120) undergoing CABG surgery were included in this study. Group-I (Study group, n=60): in which only propofol infusion used during rewarming and Group-II (control Group, n=60) in which isosorbide dinitrate and propofol infusion combination was used during rewarming. The data was entered and analyzed through SPSS Version 19. Independent sample T-test and chi-square test were used for data analysis. P value of ≤ 0.05 was taken as significant.

Results: Mean arterial pressures during rewarming were 63.41±3.61 mmHg in propofol group versus 60.80±4.86 mmHg in control group (p-value 0.001). Core temperature on weaning from cardiopulmonary bypass was 37.11±0.49 oC in propofol group and 37.00±0.18 oC in control group. After drop in core temperature was little more in propofol group (1.02±0.36 oC) versus 0.96±0.37 oC in control group but this difference was not statistically significant (p-value 0.41). Mean Ventilation time after surgery in propofol group was 4.65±0.65 hours versus 5.03±0.81 hours in control group (p-value 0.006).

Conclusion: Propofol alone is capable of fulfilling the requirements of adequate rewarming during Cardiopulmonary bypass and can produce more hemodynamic stability and early post-operative recovery.

doi: http://dx.doi.org/10.12669/pjms.324.10190

How to cite this:Furqan A, Ahmad S, Ali L, Akhtar R, Raza Baig MA, Altaf R. Comparison of effects of propofol and isosorbide dinitrate during rewarming on cardiopulmonary bypass. Pak J Med Sci. 2016;32(4):806-810.   doi: http://dx.doi.org/10.12669/pjms.324.10190

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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