Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus | Arshad | Pakistan Journal of Medical Sciences
 
میز اداری صندلی مدیریتی صندلی اداری تبلیغات کلیکی میز تلویزیون پاراگلایدر آگهی رایگان محسن چاوشی مسیح و آرش آهنگ جدید لباس زیر شورت زنانه خرید اینترنتی وبلاگدهی گن لاغری

Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus

Rabia Arshad, Muhammad Adnan Kanpurwala, Nasim Karim, Jahan Ara Hassan

Abstract


Objective: To evaluate the effects of diet control and Metformin on placental morphology in gestational diabetes mellitus (GDM).

Methods: After written informed consent 62 GDMs were enrolled. According to WHO criteria, 30 cases of GDMs with blood sugar level <130 mg/dl, were assigned Group B (2000-2500Kcal/day and 30 minute walk thrice weekly were kept on diet control and 32 cases of GDM with blood sugar level >130 mg/dl, assigned Group C were kept on diet with tablet Metformin,(500mg TDS) Finally 25 normal pregnant females were kept in Group A as control. After delivery placentae were preserved and evaluated for morphology.

Results: Heavy placentae with abundant villous immaturity, chorangiosis and syncytial knots in group B and fibrinoid necrosis and calcification in group C were seen. In group B versus A placental and cord width while in Group C versus A only cord width in gross morphology showed significant results. In group B versus A villous immaturity, chorangiosis, infarction and syncytial knots in light microscopy were present; similarly in B versus C placental width, chorangiosis and syncytial knots showed significant results, while in C versus A results were non-significant.

Conclusion: Metformin produced beneficial effects on placental morphology being comparable to normal control in contrast to diet group. 

doi: https://doi.org/10.12669/pjms.326.10872

How to cite this:Arshad R, Kanpurwala MA, Karim N, Hassan JA. Effects of Diet and Metformin on placental morphology in Gestational Diabetes Mellitus. Pak J Med Sci. 2016;32(6):1522-1527.   doi: https://doi.org/10.12669/pjms.326.10872

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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