Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy

Asmat Shaheen, Rubina Nazli Khan, Sadia Fatima, Roshan Ali, Ihsanullah Khan, Salim Khattak

Abstract


Background and Objectives: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of pre-eclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women.

Methods: This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women (gestational age >20 weeks) were included in the study with distribution as Preeclampsia (PE=86), Eclampsia (E=74) and control (N=74). Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay (ELISA) technique. SPSS version 19 was used for statistical analysis. Student’s t test was performed to evaluate the mean differences in patients and control.

Results: Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control (P value <0.001). Comparisons of mean value of visfatin with age group of 21-40 years, body mass index (BMI), primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control (p value <0.001).

Conclusion: Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women.

doi: https://doi.org/10.12669/pjms.326.10917

How to cite this:Shaheen A, Nazli R, Fatima S, Ali R, Khan I, Khattak S. Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy. Pak J Med Sci. 2016;32(6):1419-1424.   doi: https://doi.org/10.12669/pjms.326.10917

 

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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