Increasing frequency of Anti-HCV seropositivity in a cross-section of people in Karachi, Pakistan | Abdullah | Pakistan Journal of Medical Sciences
 
مبل راحتی صندلی مدیریتی صندلی اداری میز اداری وبلاگدهی گن لاغری بازی اندروید تبلیغات کلیکی آموزش زبان انگلیسی پاراگلایدر مارکت اندروید تور آهنگ محسن چاوشی مسیح و آرش پروتز سینه پروتز باسن پروتز لب میز تلویزیون

Increasing frequency of Anti-HCV seropositivity in a cross-section of people in Karachi, Pakistan

Farhan Essa Abdullah, Hamdan Ahmed Pasha, Adeel Ali Memon, Ujala Nadir Shah

Abstract


Objective: To determine the current frequency of circulating anti-HCV antibody in a cross section of subjects in Karachi, Pakistan and compare it with previous observations.
Methodology: A total of 35,191 individuals of both sexes presenting at a private diagnostic lab and its branches in Karachi city were screened for Anti-HCV antibody during a two year period ending Dec 2010. Positive tests were detected using EVOLIS automated 4th generation analyzer and confirmed with COBAS e411 random access solid phase chemiluminescent enzyme immunoassay. Also, a retrospective scrutiny of 37,391 subjects tested in the same lab during 2002-07 suggested 5.9% anti-HCV seropositivity, and was considered for comparison.
Results: Anti-HCV antibodies were detected in 3170 (9.01%) of those assessed. The youngest positive subject was a 5-day-old male neonate, the eldest an 82-year-old male. The majority of carriers (48.0%) were aged 30-49 years and 53.1% of those tested positive in Karachi, Pakistan were female. Carrier rate of anti-HCV antibody was 5.9% during 2002-07 recorded in the same lab.
Conclusion: HCV antibody frequency in our Karachi subjects have steadily increased from 5.9% in 2002-07 to 9.01% in 2009-10, encouraging awareness and enquiry of reasons for the increasing reach of a significant virus.

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