Frequency of Dyslipidemia in patients with Lupus Nephritis

Saba Sajjad, Sumaira Farman, Muhammad Ahmed Saeed, Nighat Mir Ahmad, Bilal Azeem Butt

Abstract


Objective: To determine the frequency of dyslipidemia in patients with lupus nephritis and its association with the degree of proteinuria.

Methods: This cross-sectional analytic study included 65 patients who fulfilled the ACR (American College of Rheumatology) criteria for SLE and had renal involvement, presenting to the Division of Rheumatology, Fatima Memorial Hospital (FMH), and Lahore from 21st Sep 2016 to 20th Dec 2016. After 12 hours overnight fast their blood samples were assessed for total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Patient demographic variables (age, sex) and disease characteristics (disease duration, degree of proteinuria, steroid dose) were noted. Patients were categorized into two groups on the basis of degree of proteinuria: having proteinuria >1gm or ≤ 1gm. Data was analyzed using SPSS version 22. Individual lipid profiles were correlated with the degree of proteinuria.

Results: Most common lipid abnormality found in our study was hypertriglyceridemia (58.5%). Total Cholesterol and LDL-C was high in 55.4% and 30.8% subjects respectively. Low HDL was found in 21.5% subjects. Increased frequency of dyslipidemia was noticed in those subjects who had proteinuria >1gm (P value < 0.05).

Conclusion: Dyslipidemia was observed in a high frequency in patients with lupus nephritis and was strongly associated with their degree of proteinuria.

doi: https://doi.org/10.12669/pjms.332.12410

How to cite this:Sajjad S, Farman S, Saeed MA, Ahmad NM, Butt BA. Frequency of Dyslipidemia in patients with Lupus Nephritis. Pak J Med Sci. 2017;33(2):358-362.   doi: https://doi.org/10.12669/pjms.332.12410

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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