Chronic Chlamydia pneumoniae infection and acute coronary syndrome

Abstract

Objective: Various infectious agents like Chlamydia pneumoniae have been suggested to the development of atherosclerosis. The seroepidemiological association between Chlamydia pneumoniae infection and coronary artery disease is still controversial. The aim of this study was to investigate the association between chronic Chlamydia pneumoniae infection and acute coronary syndrome.

Methodology: Eighty seven patients and 87 controls were recruited into this case-control study. Sampling was done and anti-Chlamydia pneumonia IgG and IgA (as markers of chronic infection) were measured in both groups.

Results: The overall prevalence of anti-Chlamydia pneumonia IgG and IgA were 43% and 10%, respectively. Thirty eight (43.7%) patients and 38(43.7%) controls were positive for IgG(OR=1). 8(9.2%) patients and 11(12.6%) controls were positive for IgA(OR=0.69). There was no significant difference between patients and controls in seropositivity of Chlamydia pneumoniae in uni- and multi-variate analysis.

Conclusion: There was no association between chronic Chlamydia pneumoniae infection and acute coronary syndrome in this case-control study. More investigations are suggested.