Surgical outcomes of nephrectomy for elderly patients with renal cell carcinoma

Xiaomin Gao, Liang Hu, Yue Pan, Lei Zheng


Objective: The feasibility of curative surgery for elderly patients with renal cell carcinoma (RCC) remains controversial and under discussion. The main aim of this study was to evaluate the long-term benefits of curative surgery as a treatment for RCC in elderly patients.

Methods: We retrospectively considered 672 patients with RCC who underwent partial nephrectomy or radical nephrectomy between January 2004 and July 2014. X-tile program was used to determine the optimal age cutoff values with CSS as endpoint.

Results: Patients were divided into the following groups according to their age using the method of X-tile program: a young group (< 40 years), a young-old group (40-75) and an old-old group (≥ 75). Following multivariate analysis age ≥ 75 years was determined to be an independent risk factor for overall survival (HR=4.36; 95% CI: 1.31-14.48; P=0.016); interestingly, this was not the case for cancer-specific survival (HR = 2.65; 95% CI: 0.77-9.16; P=0.124). Furthermore, an age of 40 to 75 years was not a risk factor according to univariate and multivariate analysis.

Conclusion: After determining the age cutoff values, there was no significant difference in prognosis between young and old patients with RCC.


How to cite this:Gao X, Hu L, Pan Y, Zheng L. Surgical outcomes of nephrectomy for elderly patients with renal cell carcinoma. Pak J Med Sci. 2018;34(2):288-293.   doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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