Evaluation of the effect of Retrograde Intrarenal Surgery with Myo-Inositol Oxygenase

Cuma Mertoglu, Aliseydi Bozkurt, Ercument Keskin, Murat Gunay


Objective: To investigate the effect of retrograde intra-renal sur­gery (RIRS) on kidneys using the myo-inositol oxygenase (MIOX) enzyme. MIOX is a renal tubular-specific novel marker for the early diagnosis of acute kidney injury.

Methods: A total of twenty seven individuals that had undergone RIRS to treat kidney stones were included in the study. Biochemical tests were performed on serum samples collected immediately before RIRS (hour 0) and at the 6th and 24th hours after the surgery.

Results: The creatinine value at hour 6 was lower than the baseline (hour 0) value (p = 0.0305). Cystatin C at hour 6 was lower than the value measured at hour 24 (p = 0.0142). Similarly, MIOX was lower at hour 6 compared to hour 24 (p = 0.0214). MIOX/creatinine at hour 6 was lower than the value calculated at hour 24 (p = 0.0348). The basal values of MIOX and creatinine were found to have a positive correlation (correlation coefficient r = 0.5946, p = 0.0035).

Conclusions: Similar to the serum creatinine, the serum MIOX level provides information about kidney functions. RIRS was confirmed to be a safe procedure for the treatment of acute kidney injury with no negative effects on the kidneys.

doi: https://doi.org/10.12669/pjms.341.14094

How to cite this:Mertoglu C, Bozkurt A, Keskin E, Gunay M. Evaluation of the effect of Retrograde Intrarenal Surgery with Myo-Inositol Oxygenase. Pak J Med Sci. 2018;34(1):170-174.   doi: https://doi.org/10.12669/pjms.341.14094

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Full Text: PDF


  • There are currently no refbacks.

Comments on this article

View all comments
sejuta manfaat artikel unik sejarah kerajaan