Evaluation of the children with acute acetaminophen overdose and intravenous N-acetylcysteine treatment | Yesil | Pakistan Journal of Medical Sciences
 
مبل راحتی صندلی مدیریتی صندلی اداری میز اداری وبلاگدهی گن لاغری بازی اندروید تبلیغات کلیکی آموزش زبان انگلیسی پاراگلایدر مارکت اندروید تور آهنگ محسن چاوشی مسیح و آرش پروتز سینه پروتز باسن پروتز لب میز تلویزیون

Evaluation of the children with acute acetaminophen overdose and intravenous N-acetylcysteine treatment

Yakup Yesil, Abdurrahman Avar Özdemir

Abstract


Objective: To evaluate the demographic and clinical features associated with acetaminophen overdose and to identify the clinical use of IV (intravenous) N- Acetylcysteine (NAC) treatment in children.

Methods: This prospective study was conducted in Kanuni Sultan Suleyman Training and Research Hospital between August 2016 and August 2017. A total of 59 patients with overdose acetaminophen ingestion were included in this study. The toxic dose for acute acetaminophen intake was defined as greater than 150 mg/kg. Rumack-Matthew nomogram was used to evaluate the risk of acute intoxication and to determine the decision of using antidote.

Results: The mean age of the patients was 8.5±6.4 y and 34 of them (58%) were female. The mean time from ingestion to admission was 4.3±4.7 h. The mean ingested acetaminophen dose was 142.1±80 mg/kg. Twenty four patients (41%) received NAC and there were significant differences in terms of acetaminophen dose, creatinine and INR between antidote and decontamination therapy groups at admission time (p= 0.00, p= 0.03, p= 0.02, respectively). The complication due to antidote therapy was observed in only 1 patient.

Conclusions: This study confirms that the side effects due to IV NAC therapy are uncommon and it is generally well tolerated in children. 

doi: https://doi.org/10.12669/pjms.343.14937

How to cite this:Yesil Y, Ozdemir AA. Evaluation of the children with acute acetaminophen overdose and intravenous N-acetylcysteine treatment. Pak J Med Sci. 2018;34(3):590-594.   doi: https://doi.org/10.12669/pjms.343.14937

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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