Frequency and antimicrobial susceptibility of Acinetobacter species isolated from blood samples of paediatric patients | Javed | Pakistan Journal of Medical Sciences Old Website
 

Frequency and antimicrobial susceptibility of Acinetobacter species isolated from blood samples of paediatric patients

Ayisha Javed, Aizza Zafar, Hasan Ejaz, Muhammad Zubair

Abstract


Objective: Acinetobacter species is a major nosocomial pathogen causing serious infections in immuno-compromised and hospitalized patients. The aim of this study was to determine the frequency and antimicrobial susceptibility pattern of Acinetobacter species in blood samples of paediatric patients.

Methodology: This cross sectional observational study was conducted during January to October, 2011 at The Childrens Hospital and Institute of Child Health, Lahore. A total number of 12,032 blood samples were analysed during the study period. Acinetobacter species were identified using API 20E and their antimicrobial susceptibility pattern was studied using Kirby-Bauer disc diffusion method.

Results: The blood cultures showed growth in 1,141 cultures out of which 46 (4.0%) were Acinetobacter species. The gender distribution of Acinetobacter species was 29 (63.0%) in males and 17 (37.0%) in females. A good antimicrobial susceptibility pattern of Acinetobacter species was seen with sulbactam-cefoparazone (93.0%), imepenem and meropenem (82.6% each) and piperacillin-tazobactam (78.0%). The antimicrobial susceptibility of cefixime (19.5%), co-amoxiclav and cefotaxime (23.9% each), cefuroxime (26.0%), ceftazidime and ceftriaxone (30.4%) was poor.

Conclusion: The results of the present study shows high rate of resistance of Acinetobacter species with cephalosporins in nosocomial infections. The sulbactam-cefoperazone, carbapenems and piperacillin-tazobactam showed effective antimicrobial susceptibility against Acinetobacter species.


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