Visual acuity outcomes after intra vitreal ceftazidime in acute post-operative endophthalmitis

Abstract

Objective: To determine effectiveness of ceftazidime as an intraocular antibiotic in the treatment of acute post operative endophthalmitis.

Methodology: This was an observational clinical analysis conducted on patients presenting with acute post-operative endophthalmitis. The study was conducted at Liaquat University Eye Hospital of Liaquat University of Medical and Health Sciences /Jamshoro, Pakistan. Both culture positive and negative subjects were enrolled. Anterior segment slit lamp examination and if possible posterior segment examination was performed. After completing emergency investigations, vitreous tap was carried out followed by intravitreal injection of ceftazidime (2.25%) through pars planna approach. The post-resolution best corrected visual acuity was recorded.

Result: Out of thirty four subjects, 32.4% (11 Eyes) showed good response with post treatment visual acuity of 6/24 and better. 41.2% (14) eyes had moderate improvement with visual outcome of 6/60 and better. Intravitreal injection ceftazidime was repeated on nine subjects after forty eight hours of first injection. Four (11.7%) patients out of nine with repeat injection improved to 6/60 and better, and five (14.7%) with poor response were referred to vitreo retina department.

Conclusion: Ceftazidime has proved to be quite effective in acute post operative endophthalmitis caused by both gram positive and gram negative organisms.