Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis

Abstract

Objectives: A number of studies conducted to assess the association between Clara cell 10-kDa protein (CC10) +38A/G polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results. In the present study, the possible association was assessed by a meta-analysis.

Methods: Relevant articles were identified for the period ranging from Jan 1998 up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed effects or random-effects models.

Results: Ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. The association between CC10 +38A/G polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model.  In dominant model, CC10 +38A/G polymorphism seemed to be associated with elevated asthma risk (OR = 1.62; 95% CI, 1.23-2.12; P = 0.0005). Subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in Asians and Caucasians. Results from other genetic models further identified this possible association.

Conclusion: This meta-analysis suggests that CC10 +38A/G polymorphism confers asthma risk.

doi: http://dx.doi.org/10.12669/pjms.296.3724

How to cite this:Zhao G, Lin X, Zhou M, Zhao J. Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis. Pak J Med Sci 2013;29(6):1439-1443.   doi: http://dx.doi.org/10.12669/pjms.296.3724

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