Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patientswith esophageal squamous cell carcinoma

Abstract

Objective: To study the relationship between TLR4 and NF-κB p65 protein expressions in tumor tissues after radiotherapy and clinical radiosensitivity of patients with esophageal squamous cell carcinoma.

Methods: A total of 93 patients with esophageal squamous cell carcinoma first treated in our hospital by radiotherapy and surgeries from November 2010 to December 2013 were selected. They were then divided into a severe reaction group, a moderate reaction group and a mild reaction group according to the postoperative pathological examination results of tumor tissues. The expressions of TLR4 and NF-κB p65 in the tumor samples were detected by Western blotting.

Results: Compared with the severe reaction group, the expression levels of TLR4 and NF-κB p65 in the moderate reaction group significantly increased (P < 0.05). Similarly, the expression levels of the mild reaction group were significantly higher than those of the moderate reaction group (P < 0.05).

Conclusion: Reducing the expression levels of TLR4 and NF-κB p65 proteins may increase the radiosensitivity of patients with esophageal cancer.

doi: http://dx.doi.org/10.12669/pjms.305.5472

How to cite this:Tang H, Wang F, Zhou XF, Zhou J, Chen L, Luo JD, et al. Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma. Pak J Med Sci 2014;30(5):982-985.   doi: http://dx.doi.org/10.12669/pjms.305.5472

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