Immunosuppressive effects of Rifampicin on a tuberculosis patient after renal transplant | Fu | Pakistan Journal of Medical Sciences Old Website
 

Immunosuppressive effects of Rifampicin on a tuberculosis patient after renal transplant

Yaowen Fu, Weigang Wang, Yuantao Wang, Honglan Zhou, Ping Li, Gang Wang, Boashan Gao, Wenlan Zhang, Wei An, Jinguo Wang

Abstract


Rifampicin is a semisynthetic derivative of rifamycin B and inhibits the growth of a variety of bacteria. Rifampicin causes an increase in corticosteroid clearance, and a decrease in the blood concentrations of calcineurin inhibitors by inducing Cytochrome P450 3A4 in the liver. It is generally acknowledged that a substantial increase in the dosage of calcineurin inhibitors is required to achieve the efficacious target concentrations and avoid graft rejection. We report a case of patient who received a living-related donor renal transplant with stable renal function during the rifampicin based anti-tuberculosis treatment, even the blood concentration of tacrolimus (FK506) decreased. Interestingly, acute rejection was observed at the end of anti-tuberculosis treatment, even the blood concentration of FK506 was reduced to target level.

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