Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke | Jin-he | Pakistan Journal of Medical Sciences
 

Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke

Shi Jin-he, Li-dan Niu, Xi-yan Chen, Jing-yu Hou, Ping Yang, Guang-peng Li

Abstract


Objective: We conducted a case-control study with 322 cases and 322 controls to assess the role of the two common SNPs in the promoter of IL-18 gene.

Methods: Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype -607A/C and -137C/G in the promoter of the IL-18 gene.

Results: By comparing cases and control subjects, we found that IS cases were more likely to have higher BMI, higher proportion of hypertension, and have higher proportion of smokers and drinkers. We found that IL-18 -607CC genotype (OR=1.70, 95% CI=1.03-2.81) and C allele (OR=1.26, 95% CI=1.01-1.58) were significantly more frequent in IS patients when compared with AA genotype. We did not find significant association between IL-18 -607A/C gene polymorphism and BMI, hypertension, smoking and drinking on the risk of IS.

Conclusion: Our study suggests that polymorphisms in IL-18 -607A/C can influence the development of IS, and this gene polymorphism is associated with risk of IS in a Chinese population.

doi: http://dx.doi.org/10.12669/pjms.311.5997

How to cite this:Shi JH, Niu LD, Chen XY, Hou JY, Yang P, Li GP. Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke. Pak J Med Sci 2015;31(1):198-202.   doi: http://dx.doi.org/10.12669/pjms.311.5997

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

 


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