Incidence of retinopathy in chronic Hepatitis C patientstreated with pegylated interferon alpha 2a and ribavirin combination therapy

Abstract

Objectives: The objective of this study was to determine the incidence of retinopathy in chronic hepatitis C patients treated with Pegylated interferon alpha 2a and Ribavirin.

Methods: This descriptive case series study was conducted in Medical Unit II of the Jinnah Hospital Lahore from September 2012 to February 2013. One hundred chronic hepatitis C patients visiting Medical Unit II outpatient department fulfilling inclusion criteria were selected for this study via non probability purposive sampling. Patients were started on pegylated interferon and ribavirin combination therapy. Subjects were subjected to dilated eye fundoscopic examination at the start of therapy and then after three months of the therapy.

Results: One hundred patients were included in this study. Out of these 100 patients 5% developed retinopathy whereas fundus examination was normal in rest of the patients.

Conclusion: Interferon therapy can lead to retinopathy. Periodic fundoscopic examinations help in early detection and prevent progression to permanent visual loss.

doi: http://dx.doi.org/10.12669/pjms.311.6321

How to cite this:Kashif M, Saleem MK, Farooka IK, Husnain A, Siddiqui AM. Incidence of retinopathy in chronic Hepatitis C patients treated with pegylated interferon alpha 2a and ribavirin combination therapy. Pak J Med Sci 2015;31(1):174-177.   doi: http://dx.doi.org/10.12669/pjms.311.6321

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.