|
||||
Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
||||
ISSN 1681-715X |
||||
|
||||
- |
||||
ORIGINAL ARTICLE |
||||
- |
||||
Volume 22 |
April - June 2006 |
Number 2 |
||
|
||||
|
Glimepiride study on Type-2 Diabetic Subjects
M. Zafar Iqbal Hydrie, Asma Gul, Rubina Hakeem
M. Yaqoob Ahmadani, Abdul BasitABSTRACT
Objective: The aim of the present study was to monitor the efficacy of glimepiride going beyond 4mg in our daily practice, since the action of glimepiride is reproducibly dose-dependent and the dose of glimepiride can be given upto 8 mg.
Patients and Methods: This was a prospective study in which 113 subjects (56 Males 57 Females) were recruited from the OPD of Baqai Institute of Diabetology and Endocrinology. The study started from 30th October 2003 and the last subject was enrolled on 31st July 2004. Subjects having a HbA1c > 8 % on maximum dose of other Oral Hypoglycemic Agents (OHA) were given glimepiride six to eight milligrams and treatment followed up. HbA1c was rechecked after three to six months and this was taken as subjects reaching endpoint of the study.
Results: The mean baseline HbA1c of the patients was 10.17%. The patients were followed and HbA1c done after an average of 5 months. The HbA1c of subjects continuing on 6 mg of glimepiride (n= 103) was 8.73% while those on 8 mg (n=10) was 8.26%. The adjusted mean difference of HbA1c from baseline to 2nd sample for 6mg was -1.44% and for 8 mg was -1.91% which was statistically significant (p value < 0.001). Thus the percentage reduction in mean HbA1c for 6 mg was 14.2% and for 8 mg was 18.8% respectively in our subjects.
Conclusion: The reduction of mean HbA1c before and after treatment in both the 6 and 8 mg groups was statistically significant over the period of the study.
KEY WORD: Glimepride 6mg, 8mg, Type-II Diabetes, HbA1c.
Pak J Med Sci April - June 2006 Vol. 22 No. 2 132 - 135
HOME | SEARCH | CURRENT ISSUE | PAST ISSUES
Professional
Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@pjms.com.pk