Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 22

April - June 2006

Number 2


 

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Glimepiride study on Type-2 Diabetic Subjects

M. Zafar Iqbal Hydrie, Asma Gul, Rubina Hakeem
M. Yaqoob Ahmadani, Abdul Basit

ABSTRACT

Objective: The aim of the present study was to monitor the efficacy of glimepiride going beyond 4mg in our daily practice, since the action of glimepiride is reproducibly dose-dependent and the dose of glimepiride can be given upto 8 mg.

Patients and Methods: This was a prospective study in which 113 subjects (56 Males 57 Females) were recruited from the OPD of Baqai Institute of Diabetology and Endocrinology. The study started from 30th October 2003 and the last subject was enrolled on 31st July 2004. Subjects having a HbA1c > 8 % on maximum dose of other Oral Hypoglycemic Agents (OHA) were given glimepiride six to eight milligrams and treatment followed up. HbA1c was rechecked after three to six months and this was taken as subjects reaching endpoint of the study.

Results: The mean baseline HbA1c of the patients was 10.17%. The patients were followed and HbA1c done after an average of 5 months. The HbA1c of subjects continuing on 6 mg of glimepiride (n= 103) was 8.73% while those on 8 mg (n=10) was 8.26%. The adjusted mean difference of HbA1c from baseline to 2nd sample for 6mg was -1.44% and for 8 mg was -1.91% which was statistically significant (p value < 0.001). Thus the percentage reduction in mean HbA1c for 6 mg was 14.2% and for 8 mg was 18.8% respectively in our subjects.

Conclusion: The reduction of mean HbA1c before and after treatment in both the 6 and 8 mg groups was statistically significant over the period of the study.

KEY WORD: Glimepride 6mg, 8mg, Type-II Diabetes, HbA1c.

Pak J Med Sci April - June 2006 Vol. 22 No. 2 132 - 135


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