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Volume 24 |
April - June 2008 (Part-I) |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Short Communication |
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Volume 24 |
April - June 2008 (Part-I) |
Number 2 |
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Does plasma fibrinogens and c-reactive protein predicts
the incidence of myocardial infraction in
patients with normal lipids profile?
Arun Kumar1, Ramiah Sivakanesan2
ABSTRACT
Objectives: To evaluate plasma fibrinogen and C-reactive proteins in patients with acute myocardial infarction (AMI) and compare it with normal lipid profile in healthy controls.
Methodology: Plasma fibrinogen and C-reactive proteins were determined in 165 patients and 165 age –sex matched control. The plasma fibrinogen was determined using kit, which was obtained from TECO GmbH, Dieselstr. 1, 84088 Neufahrn NB. The C-reactive protein were determined using high sensitivity enzyme Immunoassay kit manufactured by Life Diagnostics, inc. Also lipid profile was analysed enzymatically in these subjects. The values were expressed as means ± standard deviation (SD) and data from patients and controls was compared using student "t" test.
Results: Serum CRP and Plasma Fibrinogen were increased significantly (p<0.001) in AMI subjects compared to controls. High fibrinogen concentration and C-Reactive proteins seem to be important contributory risk factor in Indian CAD patients.
Conclusions: Thrombotic and inflammatory markers in combination may contribute to AMI with increased severity of the disease. Further larger studies on a nationwide basis recruiting a large number of AMI patients should be done to substantiate these findings.
KEY WORDS:
Normal lipid profile, Plasma Fibrinogen, C-Reactive proteins and AMI.Pak J Med Sci April - June 2008 (Part-I) Vol. 24 No. 2 336-339
1. Dr. Arun Kumar,
Dept. of Biochemistey,
Muzaffarnagar Medical College,
Muzaffarnagar, Uttar Pardesh,India.
2. Prof. Ramiah Sivakanesan,
Dept. of Biochemistry, Faculty of Medicine,
University of Peradeniya, Kandy, Srilanka.
E-mail: sivakanesaraminah@yahoo.com
Correspondence
Dr. Arun Kumar
E-mail: arun732003@gmail.com
* Received for Publication: September 25, 2007
* Accepted: January 26, 2008
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