Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 25

April - June 2009 (Part-I)

Number  2


 

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Influence of commiphora mukul resin on the knee
articular cartilage of rats in experimental
osteoarthritis induced by iodoacetate

Mahsa Hadipour-Jahromy1, Reza Mozaffari-Kermani2,
Fatemehsadat Nobakht3

ABSTRACT

Objective: To investigate the influence of Commiphora mukul resin (guggul) on the knee articular cartilage of rats in experimental osteoarthritis.

Methodology: To induce osteoarthritis (OA), single intra-articular injection of MIA (1 mg) in the rat knee joints was performed. Histopathological changes in knee joints were observed after two weeks. The beneficial effect of guggul was studied, orally.

Results: The early OA characterized by areas of chondrocytes degeneration in the tibial plateaus and femoral condyles. Changes to the subchondral bone and proteoglycane contents and synovial cell proliferation, were observed. Administration of guggul prevented the negative effects of iodoacetate, dose dependently. Chondrocyte damages were significantly prevented and proteoglycane were less affected, especially in high guggul dose and no cell proliferation and inflammatory cell were detected in synovial.

Conclusion: The effectiveness of guggul in improvement of histopathological damages is emphasized and its chondroprotective effect in vivo is highlighted.

KEY WORDS: Guggul, Osteoarthritis, Animal model.

Pak J Med Sci    April - June 2009    Vol. 25 No. 2    269-273

How to cite this article:

Jahromy MH, Kermani RM, Nobakht F. Influence of commiphora mukul resin on the knee articular cartilage of rats in experimental osteoarthritis induced by iodoacetate. Pak J Med Sci 2009;25(2): 269-273.


1. Mahsa Hadipour-Jahromy, Pharm.D.,
PhD of Pharmacology, Assistant Professor,
Head of Dept. Pharmacology,
Medical Sciences Research Center,
2. Reza Mozaffari-Kermani, MD, PhD of Pathology,
Assistant Professor, Dept. Pathology,
3. Fatemehsadat Nobakht, MD,
1-3: Tehran Medical Branch,
Islamic Azad University, Tehran, Iran

Correspondence

Mahsa Hadipour-Jahromy,
Zargandeh, Shariati Ave.,
Islamic Azad University, Tehran Medical Unit,
P.O. BOX: 19395-1495, Tehran, Iran
Email: jahromymh@yahoo.com 

* Received for Publication: June 16, 2008

* Revision Received: December 29, 2008

* Revision Accepted: January 1, 2009



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