Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

-

ORIGINAL ARTICLE

-

Volume 25

April - June 2009 (Part-I)

Number  2


 

Full Text
PDF of this Article

Myocardial protection by Ethyl-Isopropyl amiloride,
a specific Na+-H+ exchange inhibitor,
following Hemorrhagic Shock

Mona Soliman1, Abdul-Majid Al-Drees2

ABSTRACT

Background: Hemorrhagic shock and resuscitation is well known to result in myocardial dysfunction and injury. Stimulation of the Na+-H+ exchanger plays an important role in the pathway of myocardial injury. The purpose of the present study was to examine the protective effects of blocking the cardiac Na+-H+ exchange, using 100mM ethyl-isopropyl amiloride (EIPA), a specific Na+-H+ exchanger blocker, on myocardial contractile function on ex vivo resuscitation of isolated rat heart following one hour of hemorrhagic shock.

Methodology: Sprague- Dawley rats were assigned to hemorrhage, hemorrhage + EIPA, sham hemorrhage and sham hemorrhage + EIPA groups. Rats were hemorrhaged for one hour. Hearts were harvested and ex vivo treated and resuscitated by perfused in the Langendorff System. Myocardial function was determined.

Results: The results showed that inhibition of the Na+-H+ exchanger using EIPA improved the post-resuscitation myocardial contractile function.

Conclusion: Blocking the Na+-H+ exchanger using 100mM EIPA following 60 minutes of hemorrhagic shock improved myocardial function.

KEY WORDS: Hemorrhage, Rat, Isolated heart, Contractility, Ethyl-Isopropyl Amiloride, Langendorff.

Pak J Med Sci    April - June 2009    Vol. 25 No. 2    289-292

How to cite this article:

Soliman M, Al-Drees AM. Myocardial protection by Ethyl-Isopropyl amiloride, a specific Na+-H+ exchange inhibitor, following Hemorrhagic Shock. Pak J Med Sci 2009;25(2):289-292.


1. Dr. Mona Soliman, MBBS, MSc, PhD
Assistant Professor
2. Dr. Abdul-Majid Al-Drees, PhD
Assistant Professor
1-2: Department of Physiology
College of Medicine
King Khalid University Hospital
Riyadh - Saudi Arabia.

Correspondence

Dr. Mona Soliman, MBBS, MSc, PhD
Assistant Professor, Dept. of Physiology,
College of Medicine,
King Khalid University Hospital,
P.O. Box 2925 (29),
Riyadh – 11461,
Saudi Arabia.
E-Mail: monaslmn@yahoo.com

* Received for Publication: June 26, 2008

* Revision Received: January 21, 2009

* Revision Accepted: January 25, 2009



HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

Professional Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@