Pakistan Journal of Medical Sciences

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ORIGINAL ARTICLE

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Volume 26

April - June 2010

Number  2


 

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Non-enzymatic antioxidant status of
women using four different methods of contraception

Akinloye O1, Oyabiyi SA2, Oguntibeju OO3, Arowojolu AO4

ABSTRACT

Objective: To investigate antioxidant status of women on four different methods of contraception.

Methodology: Sixty non-pregnant women aged 16-45 years on oral contraceptive pills, injectables, Norplant and intra-uterine contraceptive devices (IUD) attending the Family Planning Clinics of the University College Hospital (UCH) and Adeoyo Maternity Hospital, Ibadan were recruited for the study. Fifty-eight apparently healthy women aged 16-45 years who were not on any contraceptive served as a control group. The body mass index (BMI) of all participants (subjects and controls) was determined following standard protocol. Serum levels of ascorbic acid, tocopherol, malondialdehyde, bilirubin, creatinine, uric acid, total protein and albumin were determined using standard spectrophotometric methods. Progesterone was estimated by the chemilumiscence method while selenium was determined by atomic absorption spectrophotometry (AAS).

Results: The BMI was significant in women on oral contraceptive pills (OCP) when compared to the control group (P<0.05) but insignificant (P>0.05) in intra-uterine device (IUD), injectables and Norplant users. The mean serum ascorbic acid (P<0.01), tocopherol (P<0.05), total protein (P<0.01), albumin (P<0.05), uric acid (P<0.05), selenium (P<0.01) of women on OCP were significantly lower when compared to the control group but insignificant (P>0.05) in users of other contraceptive methods. Serum levels of malondialdehyde was significantly elevated in women on OCP (P<0.01) than in control group and insignificant P>0.05) in users of other contraceptive methods. There was no significant association between progesterone and antioxidants in women on OCP, IUD, injectables and Norplant.

Conclusion: Oral contraceptive pills showed a significant decreasing effect on the antioxidant status of its users while IUD, injectables and Norplant did not indicate any significant effect. Routine monitoring of the antioxidant status of women on different methods of contraceptive particularly those on OCP is recommended.

KEY WORDS: Non-enzymatic; Antioxidants; Women; Contraceptives.

Pak J Med Sci    April - June 2010    Vol. 26 No. 2    374-379

How to cite this article:

Akinloye O, Oyabiyi SA, Oguntibeju OO, Arowojolu AO. Non-enzymatic antioxidant status of women using four different methods of contraception. Pak J Med Sci 2010;26(2):374-379.


1. Akinloye O,
Department of Chemical Pathology,
College of Health Sciences,
Ladoke Akintola University of Technology, Osogbo, Nigeria
2. Oyabiyi SA,
Department of Medical Laboratory Sciences,
Faculty of Basic Medical Sciences,
Ambrose Alli University, Ekpoma, Nigeria
3. Oguntibeju OO,
Department of Biomedical Sciences,
Faculty of Health & Wellness Sciences,
Cape Peninsula University of Technology,
Bellville, South Africa
4. Arowojolu AO,
Department of Obstetrics & Gynaecology,
College of Medicine,
University of Ibadan, Ibadan, Nigeria.

Correspondence:

Dr. O.O. Oguntibeju
Dept. of Biomedical Sciences, Faculty of Health &
Wellness Sciences,Cape Peninsula University of
Technology, Bellville Campus 7535, South Africa.
Email: oguntibejuo@cput.ac.za

* Received for Publication: September 19, 2009
* Revision Received: January 26, 2010
* Revision Accepted: February 1, 2010



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