Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

April - June 2007 (Part-II)

Number 3


 

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Resistance to vancomycin in enterococcus
faecium and faeca lis clinical isolates

A. Aleyasin1, A.M. Mobarez2, M. Sadeghizadeh3, R. Hosseini Doust4, N. Khoramabadi5
 

ABSTRACT
The aim of this study was to investigate antibacterial resistance among enterococci species isolated in Tehran Baghyatallah Hospital. It consisted of 126 isolates of E. faecalis (86%), E. faecium (9%) and other Enterococus Spp. (5%) isolated from urine (34.92%), blood (27.77%), wound swabs (19.84), stool (5%) endotracheal secretions (3.37%), abscess (3.4%), dialysis fluids (1.7%) and catheter (4%). Twelve (9.5%) isolates were resistant to vancomycin. The VRE isolates were resistant to ampicillin (75%), erythromycin (50%), tetracycline (58%), ciprofloxacin (41.6%), chloramphenicol (33.3%) and gentamicin (41.6%). Two (16.66%) of VRE isolates were multidrug resistant. Eight (66.6%) of the vancomycin-resistant strains and all of the MDR strains carried the vanA phenotype and genotype. The MIC of VRE isolates were between 32-512g/ml. Our results show that most glycopeptide resistant E. faecalis and E. Faecium carried vanA. It is also possible that frequency of infections caused by glycopeptide-resistant enterococci will increase in our geographical area.

KEY WORDS: Enterococcus, Clinical Samples, VanA, Vancomycin-resistant Enterococci, Iran.

Pak J Med Sci   May - June 2007   Vol. 23 No. 3    390-393


1. A. Aleyasin,
2. Dr. A. M. Mobarez,
3. Dr. M. Sadeghizadeh,
Department of Genetic, Faculty of Basic Sciences,
4. Dr. R. Hosseini Doust,
Dept. of Microbiology &
Research Center of Molecular Biology,
Baghyatollah University, Tehran Iran.
5. N. Khoramabadi,
1,2,5: Department of Bacteriology,
Faculty of Medical Sciences,
1,3,5: University of Tarbiat Modares,
Tehran Iran.

Correspondence

Dr. A. M. Mobarez,
E-mail: mobares80@yahoo.com

* Received for Publication: September 26, 2006
* Accepted: January 28, 2007



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