|
|
||||
|
Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
||||
|
ISSN 1681-715X |
||||
|
||||
|
- |
||||
|
ORIGINAL ARTICLE |
||||
|
- |
||||
|
Volume 23 |
April - June 2007 (Part-II) |
Number 3 |
||
|
|
||||
|
||||
|
|
||||
|
Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
||||
|
ISSN 1681-715X |
||||
|
||||
|
- |
||||
|
ORIGINAL ARTICLE |
||||
|
- |
||||
|
Volume 23 |
April - June 2007 (Part-II) |
Number 3 |
||
|
|
||||
|
||||
Effect of zinc supplementation of pregnant rats on
short-term & long-term memory of their offspring
Moazedi Ahmad Ali1, Ghotbeddin Z2, Parham GH3ABSTRACT
Objective: To see the dose dependent effects of zinc chloride on the short-term and long-term memory in a shuttle box (rats).
Methodology: Six pair adult wistar rats were taken for this experiment. One group of pregnant rats received a daily oral dose of 20mg/kg Zn as zinc chloride and the remaining groups received a daily oral dose of (30, 50, 70,100mg/kg) zinc chloride for two weeks by gavage. One month after birth, a shuttle box was used to test short-term and long-term memory. Two criteria were considered to behavioral test, including latency in entering dark chamber and time spent in the dark chamber.
Result: This experiment showed that oral administration of ZnCl2 with (20, 30, 50 mg/kg/day) doses after 2 weeks at the stage of pregnancy, can improve the working memory of their offspring (p<0.05). Where as ZnCl2 with 30mg/kg/day dose has been more effective than other doses (p<0.001). But rat which received ZnCl2 with 100mg/kg/day at the stage of pregnancy, has shown significant impairment in working (short-term) memory of their offspring (p<0.05) and there was no significant difference in reference (long-term) memory 3 for any of groups.
Conclusion: This study has demonstrated that zinc chloride consumption with 30mg/kg/day dose for two weeks at the stage of pregnancy in rats, has positive effect on short-term memory on their offspring. But consumption of enhanced zinc 100mg/kg/day in pregnant rats can cause short-term memory impairment. On the other hand, zinc supplementation such as zinc chloride has no effect on long-term memory.
KEY WORDS: Zinc, Gestation, Offspring, Memory, Rat.
Pak J Med Sci May - June 2007 Vol. 23 No. 3 405-409
1. Dr. Moazedi Ahmad Ali,
2. Dr. Ghotbeddin Z,
1-2: School of Science, Biology Department,
Shahid Chamran University,
Ahwaz, Iran.
3. Dr. Parham GH,
School of Mathematic, Statistic Department,
Shahid Chamran University, Ahwaz, Iran.
Correspondence
Dr. Moazedi Ahmad Ali
Department of Biology, School of Science,
Shahid Chamran University,
Postal Code: 65355- 141,
Ahvaz - Iran.
Email: moazedi_a@yahoo.com
* Receive for Publication: November 11, 2006
* Revision Received: November 15, 2006
* 2nd Revision Received: February 14, 2007
* Accepted: March 8, 2007
HOME | SEARCH | CURRENT ISSUE | PAST ISSUES
Professional
Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@pjms.com.pk
