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Volume 24 |
April - June 2008 (Part-II) |
Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 24 |
April - June 2008 (Part-II) |
Number 3 |
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Evaluation of Clopidogrel in
Inhibition of Platelet Aggregation
Naeem Aslam1, Hafiz Rashid Mehmood2,
Abdul Hafeez Chaudhry3,
Waqar Shamim4, Mehmood Ismail5, Asim Awan6
ABSTRACT
Objective: Evaluation of In-vivo therapeutic effects of Clopidogrel 75mg (Lowplat) given once daily for seven days to the patients requiring antiplatelet therapy.
Methodology: This is an open label, multicenter study to determine the platelet aggregation inhibition of the study drug in adult subjects suffering from diseases requiring antiplatelet therapy i.e. coronary artery diseases (CAD), peripheral vascular diseases (PVD) and cerebro vascular accident (CVA), presented at different hospitals and clinics in Faisalabad.
Results: Mean platelet aggregation inhibited by (LP) was 66% (P <0.001) and standard deviation was ± 10%, which is statistically significant.
Conclusion: This study proves that the Lowplat (LP) is effective in reducing platelet aggregation significantly in Pakistani patients’ who require antiplatelet therapy. The cost benefit of locally manufactured drug may be passed on to the patients.
KEYWORDS: Clopidogrel, Antiplatelet therapy, Platelet Aggregation inhibition.
Pak J Med Sci April - June 2008 (Part-II) Vol. 24 No. 3 420-424
How to cite this article:
Aslam N, Mehmood HR, Chaudhry AH, Shamim W, Ismail M, Awan A. Evaluation of Clopidogrel in Inhibition of Platelet Aggregation. Pak J Med Sci 2008;24(3):420-4 .
1. Dr. Naeem Aslam,
Head of Cardiology Punjab Medical College &
Allied Hospital, Faisalabad.
2. Dr. Hafiz Rashid Mehmood,
Afzal Clinic Kotwali Road, Faisalabad.
3. Dr. Abdul Hafeez Chaudhry,
Head Department of Medicine,
Punjab Medical College & Allied Hospital Faisalabad,
4. Dr. Waqar Shamim,
Aziz Fatima Hospital Faisalabad,
5. Dr. Mehmood Ismail,
Allah Rakhi Hospital, Faisalabad,
6. Dr. Asim Awan,
Clinision, Karachi - Pakistan.
Correspondence
Dr. Asim Awan,
CLINISION, 402, Business Avenue,
P.E.C.H.S., Block – 6,
Main Shahrah-e-Faisal
Karachi. Pakistan.
E mail: drasimawan@yahoo.com
* Received for publication: November 29, 2007
* Revision Received: April 11, 2008
* 2nd Revision Received: May 19, 2008
* Final Revision Accpeted: May 20, 2008
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