Sensitivity pattern of methicillin resistant and methicillin
sensitive Staphylococcus aureus isolates, against several
antibiotics including tigecycline in Iran: A hospital based study

Mohammad Aghazadeh¹, Mohammad Rahbar²,
Mohammad Kabeh Monnavar³, Fatemeh Savaheli Moghadam⁴

ABSTRACT

Objectives: Methicillin resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen causing significant morbidity and mortality. The aim of this study was to evaluate in vitro activity of tigecycline and other new agents against MRSA, isolated from surgical wound and soft tissue infections in an Iranian 1000-bed tertiary hospital.

Methodology: In vitro activity of tigecycline and other antibiotics were tested against 102 strains of Staphylococcus aureus isolated from different patients hospitalized at Milad hospital from May 2008 to June 2008. All strains were identified according to routine bacteriological methods. Susceptibility testing was performed by disk diffusion methods as recommended by Clinical Laboratory Standards Institute (CLSI). Cefoxitin (30µg) disk used for detection of methicillin resistant strains of S.aureus.

Results: One hundred two strains of S.aureus were isolated from patients admitted to our hospital. The majority of patients was from surgical wards including open heart, orthopedic ward and had post operation wound infections. Of 102 strains 36(35.3%) isolates were MRSA. All isolates including MRSA strains were susceptible to tigecyline, linozolide and vancmycin. Of 102 isolated strains 96 (94.1%) were susceptible to teicoplanine and six stains (5.9%) were intermediate. Resistant rate to other antibiotics including clindamycinm erythromycin pencillin, co-trimoxazole, rifampicin and ciprofloxacin were 35.3%, 27.7%, 97.7%, 26.5%, 16.7%and 33.7% respectively.

Conclusion: All strains of S.aureus, isolated from wound and soft tissue in our hospital were susceptible to tigecyline, linozolide and vancomycin.

KEY WORDS: Methicillin Resistance, Staphylococcus aureus, Wound infection, Antimicrobial agents.

Pak J Med Sci    April - June 2009 (Part-II)    Vol. 25 No. 3    443-446

How to cite this article:

Aghazadeh M, Rahbar M, Monnavar MK, Moghadam FS. Sensitivity pattern of methicillin resistant and methicillin sensitive Staphylococcus aureus isolates, against several antibiotics including tigecycline in Iran: A hospital based study. Pak J Med Sci 2009;25(3): 443-446

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1. Mohammad Aghazadeh
Dept. of Microbiology,
Faculty of Medicine,
Tabriz University of Medical Sciences,
Tabriz, Iran.
2. Mohammad Rahbar,
Department of Microbiology,
Iranian Reference Health Laboratories,
Tehran, Iran.
3. Mohammad, Kabeh - Monnavar,
4. Fatemeh. Savaheli Moghadam
3-4: Dept. of Infection Control,
Milad Hospital,
Tehran, Iran.

Correspondence

Mohammad Rahbar (PhD),
Department of Microbiology,
Iranian Reference Health Laboratory,
Tehran, Iran.
E-mail: mhhf_rz@yahoo.com

* Received for Publication: November 10, 2008
* Revision Received: March 16, 2009
* Revision Accepted: April 5, 2009

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