A comparison of the effect of oral paracetamol and
clonidine on pediatric preoperative anxiety
in adenotonsillectomy

S Abbas Hosseini Jahromi¹, S Massumeh Hosseini Valami², N Naseh³

ABSTRACT

Objective: To see the effect of oral paracetamol and clonidine on pediatric preoperative anxiety in adenotonsillectomy.

Methodology: The participants of this double blind clinical trial study consisted of 120 children. Their age range was between 3-12 years. They were in ASA class I of anesthesia and were chosen for elective adenotonsillectomy in Qods hospital in Qazvin, Iran.

The patients were randomly divided in three equal groups. One group received paracetamol 20 mg/kg, another group received 4mcg/kg clonidine orally 60-90 minutes before operation and the third group received placebo. As the first step, in order to do the statistical analysis, intensity of preoperative anxiety had been evaluated by Modified-Yale Preoperative Anxiety Scale (m-Yale PAS) and data were transformed to the SPSS software. Then different statistical procedures like Chi-square, One way Annova and Tukey test were performed.

Results: There was no significant difference (statistical) of age, weight and sex among three groups. Mean score of anxiety was significantly lower in paracetamol and clonidine’s groups than placebo’s group, but there was no significant statistical difference between paracetamol and clonidine’s groups in decreasing preoperative anxiety score.

Conclusions: Oral paracetamol like oral clonidine decreases preoperative anxiety score. Thus one can use paracetamol instead of clonidine.

KEY WORDS: Paracetamol, Clonidine, Preoperative anxiety.

Pak J Med Sci    April - June 2009 (Part-II)    Vol. 25 No. 3    458-461

How to cite this article:

Jahromi SAH, Valami SMH, Naseh N. A comparison of the effect of oral paracetamol and clonidine on pediatric preoperative anxiety in adenotonsillectomy. Pak J Med Sci 2009;25(3): 458-461.

---

1. S Abbas Hosseini Jahromi, MD
2. S Massumeh Hosseini Valami, MD
3. N Naseh, MD
1-3: Department of Anesthesiology,
Rajaee Hospital,
Qazvin, Iran.

Correspondence

S Abbas Hosseini Jahromi,
Department of Anesthesiology,
Rajaee Hospital,
Qazvin, Iran.

Email: papaya812002@yahoo.com

* Received for Publication: October 16, 2008
* Accepted: April 14, 2009

---

HOME   |   SEARCH   |   CURRENT ISSUE   |   PAST ISSUES

Professional Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@