Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

January - March 2007

Number 1


 

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Resistant gram-negative bacilli and antibiotic
consumption in Zarqa, Jordan

Hussein A Bataineh1, Khalid M Alrashed2

ABSTRACT

Objective: To investigate the prevalence of antibiotic resistance among gram-negative bacteria in relation to antibiotic use in Prince Hashem Hospital (PHH), Jordan.

Materials and Methods: One hundred consecutive gram-negative bacterial isolates from different sites were collected from patients admitted to the ICU at PHH. The susceptibilities of the strains to 12 antibiotics were performed and interpreted. The quantities and the numbers of the patients discharged on antibiotics and the quantities consumed were obtained from the hospital pharmacy records.

Results: The most common isolate was P. aeruginosa (n=21) The most common site of isolation was the respiratory tract (65%), The highest susceptibility was to piperacillin/ tazobactam(78%), and the lowest was to cefuroxime(34%). The aminoglycosides gentamicin and amikacin were active against 71% and 73% of the isolates respectively, Ciprofloxacin was active against 75% of the isolates. The most frequently used antibiotics were the third-generation cephalosporins ceftriaxone and ceftazidime, followed by imipenem and amikacin.

Conclusion: Antibiotic resistance surveillance programs associated with registration of antibiotic consumption are necessary to promote optimal use of antibiotics. Rational prescribing of antibiotics should be encouraged through educational programs, surveillance and audit. Proper infection control measures should be practiced to prevent horizontal transfer of drug-resistant organisms.

Key words: Antibiotic, Resistance, Gram-Negative Bacilli.

Pak J Med Sci January - March 2007 Vol. 23 No.1  59-63


1. Dr. Hussein A Bataineh
2. Dr. Khalid M Alrashed

1-2: Prince Hashem Hospital,
P.O. Box: 206,
Aidoun 2116,
Jordan.

Correspondence:
Dr. Hussein A Bataineh,
E-Mail: hussein_azzam@yahoo.com

* Received for Publication: March 15, 2006
* Accepted: September 14, 2006



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