Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

January - March 2007

Number 1


 

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Ciprofloxacin resistance among bacterial isolates in a
teaching hospital in Riyadh Saudi Arabia 2001-2005

Hanan Ahmed Habib Babay1

ABSTRACT

Objective: To present trends of resistance to ciprofloxacin among common organisms isolated at King Khalid University Hospital (KKUH) between 2001-2005.

Methods: Ciprofloxacin susceptibility of all isolates of Gram negative and Gram positive organisms were retrospectively obtained during the period from 2001-2005 in KKUH. Data from intensive care unit (ICU) and non-ICU patients were separately analyzed.

Results: Escherichia coli (E.coli) resistance increased from 10% in 2001 to 22% in 2005. Enterobacter cloacae (Ent.cloacae) resistance decreased from 11-14% in 2003 -2004 to 7% as in 2001 and 2005. Klebsiella pneumoniae ( K.pneumoniae) resistance fluctuated from 6% in 2002 and 2003, 13% in 2004 to 6% in 2005. Pseudomonas aeruginosa ( P.aeruginosa ) resistance ranged from 7% - 8% during this study period while that of Acinetobacter spp. ranged between 45% to 62% and Staphylococcus aureus ( S.aureus) resistance doubled from 18% in 2001 to 39% in 2005. None of Streptococcus pneumoniae (S.pneumoniae) isolates showed resistance to ciprofloxacin. Isolates of E .coli, Acinetobacter spp. and S.aureus from non-ICU patients showed higher resistance to ciprofloxacin than isolates from ICU patients while K.pneumoniae and P.aeruginosa showed higher resistance from ICU patients than isolates from non-ICU patients.

Conclusion: Ciprofloxacin resistance among many Gram negative species and S.aureus is an increasing threat among many Gram negative species and S.aureus in our hospital in both ICU and non-ICU patients.

KEY WORDS: Ciprofloxacin resistance, E.coli, K.pneumoniae, Ent.cloacae, P.aeruginosa, Acinetobacter spp, S.aureus, S.pneumoniae, Intensive care unit, Misuse of antibiotics.

Pak J Med Sci January - March 2007 Vol. 23 No.1  39-42


1. Dr. Hanan Ahmed Habib Babay
Associate Professor, Consultant Medical Microbiologist
Department of Pathology, Microbiology Unit
King Khalid University Hospital
Riyadh, Saudi Arabia

Correspondences:
Dr. Hanan A.H.Babay
Department of Pathology,
Microbiology, (32)
King Khalid University Hospital,
PO Box 2925,
Riyadh – 11461,
Saudi Arabia.
E-Mail: hahabib@ksu.edu.sa

* Received for Publication: April 17, 2006
* Accepted: September 14, 2006



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