Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 24

January - March 2008

Number  1


 

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Prevalence and antibiotic resistance among helicobacter pylori
clinical isolates from main Hospitals in the
Western Region of Saudi Arabia

Aiman M. Momenah1, Atif H. Asghar2

ABSTRACT

Objective: The aim of this study was to evaluate the antimicrobial susceptibility patterns amongst H. pylori clinical strains isolated from the main hospitals in the western region of Saudi Arabia.

Methodology: Antimicrobial susceptibility testing was performed for 137 clinical isolates of H. pylori recovered from 368 Saudi patients undergoing endoscopic examination. The antibiotics used were amoxicillin, tetracycline, clarithromycin and metronidazole.

Results: A high percentage of resistance were observed against metronidazole (48.2%) followed by clarithromycin (27.7%), amoxicillin (14.6%) and tetracycline (9.5%). A total of 12 (8.8%) multidrug-resistant H. pylori isolates were observed in this study. Moreover, a warning sign of emerging resistance to amoxicillin, tetracycline and clarithromycin were noted.

Conclusion: The clinician need to be aware about resistance pattern in their region when they select empiric antibiotics regimen for H. pylori.

KEYWORDS: Helicobacter pylori, Antibiotic resistance, Gastritis, Peptic ulcer, Gastric cancer.

Pak J Med Sci    January - March 2008    Vol. 24 No. 1    100-103


1. Aiman M. Momenah,
Assistant Prof. of Med Microbiology,
Department of Medical Microbiology,
Faculty of Medicine and Medical Sciences,
2. Atif H. Asghar,
Associate Prof. of Med Microbiology,
Department of Environmental and Health Research,
The Custodian of the two Holly Mosques
Institute for Hajj Research,
1-2: Umm Al-Qura University,
Makkah- Saudi Arabia.

Correspondence

Dr. Atif H. Asghar,
Umm Al-Qura University,
The Custodian of the Two Holy Mosques,
Institute for Hajj research, P.O. Box: 6287
Makkah, Saudi Arabia.
E-mail: asghar1000@hotmail.com

* Received for Publication: January 15, 2007

* Revision Accepted: December 1, 2007



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