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Volume 26 |
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Number 1 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 26 |
January - March 2010 |
Number 1 |
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Latent tuberculosis infection in individuals with human
immunodeficiency virus infection: Comparison of tuberculin
skin test to the anti TB-IgM antibodiesSeyed Mohammad Alavi1, Mohammad Nadimi2,
Shahram Shokri3, Gholamabbas Zamani4ABSTRACT
Objective: To determine Latent Tuberculosis Infection (LTBI) prevalence and compare TST results to the anti TB-IgM anti bodies (ATIA) for the diagnosis of LTBI in HIV infected individuals.
Methodology: Sixty two randomized sampled HIV infected subjects from an addict treatment center in Ahvaz southwest Iran underwent TST, using 5 TU of purified protein derivative, and measuring ATIA. Data were analyzed in SPSS (version 16, USA).
Results: Of 62 participants, 34 (54.8%) had positive result for TST, whereas 6(9.7%) had positive ATIA. Overall concordance between TST and ATIA was 45.2% (Kappa= 0.37, P = 0.32). In subjects with positive test results by either TST or ATIA, only 4.8% had positive test results by both tests. Discordant results were found in 54.8% of subjects. Positive results for both tests in subjects categorized in two groups (above and below 200 CD4-cell/mm3) had no significant difference (P>0.05).
Conclusion: LTBI prevalence among HIV infected individuals in studied area is higher than other parts of the world. TST is a useful test for LTBI diagnosis and prefer to ATIA. Concordance between TST and ATIA is low.
KEY WORDS:
Human immunodeficiency virus, Latent tuberculosis infection, IgM anti M.tuberculosis antibody, Tuberculin skin test.Pak J Med Sci January - March 2010 Vol. 26 No. 1 11-14
How to cite this article:
Alavi SM, Nadimi M, Shokri S, Zamani GA. Latent tuberculosis infection in individuals with human immunodeficiency virus infection: Comparison of tuberculin skin test to the anti TB-IgM antibodies. Pak J Med Sci 2010;26(1):11-14
1. Dr. Seyed Mohammad Alavi, MD.
Associated Professor,
Joundishapour Infectious and Tropical Diseases
Research Center, No: 52, West 11 Avenue,
Kianabad, Ahvaz, Iran
2. Dr. Mohammad Nadimi, MD
3. Dr. Shahram Shokri, MD
1-3: Infectious Disease Ward, Razi Hospital,
Joundishapour University of Medical Sciences,
Ahvaz, Iran.
4. Gholamabbas Zamani, BS
Health Ministry of Iran
Correspondence
Dr. Seyed Mohammad Alavi
Email:alavi1329dr@yahoo.com
* Received for Publication: May 13, 2009
* Accepted: January 1, 2010
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