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Volume 26 |
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Number 1 |
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Volume 26 |
January - March 2010 |
Number 1 |
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Intravenous Sufentanil and Morphine for Post-Cardiac
Surgery Pain Relief Using Patient-Controlled Analgesia
(Pca) Device: A Randomized Double-Blind Clinical TrialSeyed Mostafa Alavi1, Rasoul Ferasat Kish2, Fariborz Farsad3,
Farnad Imani4, Mehrdad Sheikhvatan5ABSTRACT
Background: Selection of the best analgesic technique in patients undergoing major surgeries can result in lower morbidity and satisfactory postoperative pain relief. In the present study, we tried to compare the effect of morphine and sufentanil on postoperative pain severity and hemodynamic changes by using patient-controlled analgesia (PCA) device in patients who were candidate for coronary artery bypass surgery (CABG).
Methodology: It was a randomized double-blinded clinical trial in which 120 patients aged 30-65 years, ASA physical status I-III, candidate for CABG in Shahid Rajaee hospital in Tehran were included. Before anesthesia, patients were randomly assigned to one of three groups to receive sufentanil (n=40), morphine (n=40) or normal saline (n=40). After tracheal extubation at intensive care unit, PCA was started by, sufentanil 4mg for the first group, morphine 2mg for the second group and normal saline, at same volume for the third group, intravenously with 10 minute lockout interval. Postoperative pain was evaluated by VAS scale, 1, 6, 12, 18 and 24 hours after extubation and systolic blood pressure, arterial oxygen saturation, PCO2 and PO2 were recorded 24 hours after extubation.
Results: VAS scores at rest revealed significantly less pain for patients in sufentanil and morphine groups than normal saline group, throughout the twenty-four hours after operation (P<0.001). However, there were no significant differences in the means of VAS scores between sufentanil and morphine groups. Among studied hemodynamic parameters, only systolic blood pressure was reduced more in morphine than sufentanil group (P<0.001).
Conclusion: After CABG surgery, administration of intravenous sufentanil and morphine using PCA can lead to similar reduction of postoperative pain severity.
KEYWORDS:
Pain, Sufentanil, Morphine, Coronary artery bypass grafting.Pak J Med Sci January - March 2010 Vol. 26 No. 1 137-141
How to cite this article:
Alavi SM, Kish RF, Farsad F, Imani F, Sheikhvatan M. Intravenous Sufentanil and Morphine for Post-Cardiac Surgery Pain Relief Using Patient-Controlled Analgesia (Pca) Device: A Randomized Double-Blind Clinical Trial. Pak J Med Sci 2010;26(1):137-141
1. Seyed Mostafa Alavi
2. Rasoul Ferasat Kish
3. Fariborz Farsad
4. Farnad Imani
5. Mehrdad Sheikhvatan
1-5: Iran University of Medical Sciences,
Tehran - Iran.Correspondence:
Seyed Mostafa Alavi,
Iran University of Medical Sciences,
P.O.Box: 13185-1678,
Tehran, Iran
Email: swt_f@yahoo.com
* Received for Publication: August 25, 2009
* Accepted: January 6, 2010
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