Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 23

July - September 2007

Number  4


 

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Effectiveness of high-dosage mitomycin-c in trabeculectomy:
High risk patients with glaucoma

Fereshtekhou MA1, Zarghami N2

ABSTRACT

Objective: To evaluate the effectiveness of high-dosage mitomycin-C (MMC) in patients with glaucoma undergoing trabeculectomy and its use for preventing failure of operation.

Methodology: We used 0.5mg/ml MMC for 5 minutes during trabeculectomy operation for twenty patients with glaucoma (twenty eyes). MMC was applied on episclera without any contact with the wound. Patients were followed-up for twelve months. Success of operation by the use of high-dosage MMC was defined with intraocular pressure (IOP) between 5 and 20mmHg together with decline of snellen visual acuity not more than two lines.

Results: Trabeculectomy together with high-dosage MMC led to decline of IOP on an average of 66%. The mean preoperative IOP was 34.8±5.16 mmHg and the mean postoperative IOP was 12.6±2.93 mmHg. The difference between preoperative and postoperative IOP was statistically significant (p<0.05). Of the twenty patients, 100% had successful operation, 90% had formation of thin avascular bleb, 25% had postoperative leakage, 20% had shallow anterior chamber, 20% had choroids effusion, and 10% had cataract at postoperative evaluation.

Conclusion: High-dosage Mitomycin-C is safe & effective for high risk patients with glaucoma who undergo trabeculectomy and it leads to significant control of IOP if postoperative complications are managed and treated as well.

KEY WORDS: Mitomycin-C, Trabecolectomy, Intraocular, Glaucoma.

Pak J Med Sci   July - September 2007   Vol. 23 No. 4   526-529


1. Fereshtekhou MA,
Department of Ophthalmology,
Nikoukari Teaching Hospital,
Tabriz University of Medical Sciences,
Tabriz – Iran.
2. Zarghami N
Department of Clinical Biochemistry and RIA,
Drug Applied Research Center, Tabriz – Iran.

Correspondence

Fereshtekho MA
E-mail: drferesh@yahoo.com

* Received for Publication: October 30, 2007
* Revision Received: January 4, 2007
* Revision Accepted: April 18, 2007


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