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ORIGINAL ARTICLE
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Volume 23	July - September 2007	Number  4
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The effect of grape seed extract (GSE)
on spatial memory in aged male rats

Alireza Sarkaki¹, Yaghoub Farbood², Mohammad Badavi³

ABSTRACT

Objective: To test the effect of GSE on spatial memory in aged male rats.

Methodology: We hypothesized that ingestion of polyphenols-enriched preparation such as GSE would be manifested as cognitive-enhancement that would be consistent with neuroprotection in aged rats. Aged male rats were divided into two groups (control and GSE treated). Control rats received normal saline and treated rats received GSE (100mg/kg) by oral gavage for 30 days. They trained in Morris water maze.

Results: Our data showed that administration of grape seed extract to aged rats improves memory retention in water maze performance.

Conclusion: Based on the results of the Morris water maze tests using aged rats, we found that GSE had remarkable cognitive-enhancing effect.

KEY WORDS: GSE, memory, aging, Water maze, Rat.

Pak J Med Sci   July - September 2007   Vol. 23 No. 4   561-565

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1. Dr. Alireza Sarkaki,
Associate Professor of Physiology
2. Dr. Yaghoub Farbood,
Ph.D Student,
3. Dr. Mohammad Badavi,
Assistant Professor of Physiology,
1-3: Physiology Research Center,
Ahwaz Jondi-Shapour University of Medical Sciences,
Ahwaz – Iran.

Correspondence

Dr. Alireza Sarkaki,
E-Mail: sarkaki_a@yahoo.com

* Received for Publication: December 7, 2006
* Revision Received: December 21, 2006
* Accepted: April 2, 2007

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