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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
July - September 2007 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 23 |
July - September 2007 |
Number 4 |
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Gastroprotective effect of alhagi maurorum
on exprimental gastric ulcer in ratsMohhammad Kazem Gharib Naseri1, Seyyed Ali Mard2
ABSTRACT
Objectives: Alhagi maurorum belongs to the family Leguminosae is used in Iranian folk medicine to treat gastric disturbances. The present study was undertaken to evaluate the Alhagi maurorum aqueous extract (AME) for anti-ulcer activity in rat.
Methodology: Male Wistar rats were pretreated with the AME (150, 300 and 450mg/kg, P.O.) before induction of gastric ulcer by water immersion restraint-stress (5 h, water immersion restraint stress at (20-22°C) or ethanol (100%; 1ml/200g of B.W, P.O). Negative control animals received saline (0.5ml/100g of B.W) & positive control animals received ranitidine (60mg/kg, P.O).
Results: The AME protected rats against water immersion restraint-stress and ethanol-induced ulcers in a dose-dependent manner. In water immersion restraint induced ulcerated rat, the AME increased pH and reduced gastric acid content. AME did not show any signs of toxicity and mortality up to10g/kg, P.O. in mice.
Conclusion: The results suggest that AME has significant mucosal protective and antisecretory effects on gastric mucosa in rats.
KEY WORDS: Alhagi maurorum, Antiulcer activity, Rat.
Pak J Med Sci July - September 2007 Vol. 23 No. 4 570-573
1. M. Kazem Gharib Naseri, Associate Prof. of Physiology,
2. Seyyed Ali Mard,
Ph.D Student of Physiology, Dept. of Physiology,
1-2: School of Medicine,
Ahwaz Jondi Shapour University of Medical Sciences,
Ahwaz – Iran.
Correspondence
Seyyed Ali Mard,
E-mail: a_mard2003@yahoo.com
* Received for Publication: December 8, 2007
* Revision Received: April 27, 2007
* Revision Accepted: May 2, 2007
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