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Volume 23 |
July - September 2007 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Volume 23 |
July - September 2007 |
Number 4 |
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Alpers disease: Report of two familial cases
M. Barzegar1, Mazyar Hashemilar2
ABSTRACT
Alpers syndrome is usually characterized by a clinical triad of psychomotor retardation, intractable epilepsy and liver failure in infants and young children. It is a hereditary disease with an autosomal recessive pattern of inheritance. Definitive diagnosis is shown by postmortem examination of the brain and liver. There is no known treatment. In this article two familial cases are reported.
KEY WORDS: Alpers syndrome, Neuronal degeneration, Liver disease, Progressive cerebral poliodystrophy.
Pak J Med Sci July - September 2007 Vol. 23 No. 4 643-646
1. M. Barzegar,
Associate Professor of Pediatric Neurology,
Tabriz Children’s Hospital,
2. Mazyar Hashemilar,
Assistant Professor of Neurology,
1-2: Tabriz University of Medical Sciences,
Tabriz – Iran.
Correspondence
Mazyar Hashemilar,
Razi Hospital,
El Goli Road,
Tabriz – Iran.
E-mail: mhashemilar@yahoo.com
* Received for Publication: March 19, 2007
* Revision Received: March 24, 2007
* Accepted: June 5, 2007
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