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Volume 24 |
July - September 2008 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 24 |
July - September 2008 |
Number 4 |
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The effect of Epstein–Barr virus Latent Membrane
Protein-1 status on outcome of patients
with classic Hodgkin’s Lymphoma
Mohammad-Ali Rajabi1, Parvin Rajabi2,
Amin Eftekhari3,
Mehdi Eftekhari4, Hamid Reza Ghasemibasir5, Ali-Reza
Mesbah6
ABSTRACT
Objective: This study determines the expression of latent membrane protein-1(LMP-1) in lymph nodes of patients with classic Hodgkin lymphoma (cHL) and its role in patients’ survival.
Methodology: Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival (DFS) was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy.
We investigated the expression of LMP-1in outcome of patients with cHL.
Results: LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight (25.5%) patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% (P= 0.005). Patients with EBV-positive tumors had fewer DFS (22.6 vs. 25.9 mo), but the difference was not statistically significant (p=0.06).
Conclusion: Although in our study there is no relationship between age and LMP-1expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL.
KEYWORDS: Classic Hodgkin lymphoma, Latent membrane protein-1, LMP-1, Epstein-Barr virus, EBV, Survival.
Pak J Med Sci July - September 2008 Vol. 24 No. 4 531-536
How to cite this article:
Rajabi MA, Rajabi P, Eftekhari A, Eftekhari M, Ghasemibasir HR, Mesbah AR.The effect of Epstein–Barr virus Latent Membrane Protein-1 status on outcome of patients with classic Hodgkin’s Lymphoma. Pak J Med Sci 2008;24(4):531-6.
1. Mohammad-Ali Rajabi,
Associate Professor of Surgery,
2. Parvin Rajabi,
Professor of Pathology,
3. Amin Eftekhari,
Resident of Pathology
4. Mehdi Eftekhari,
5. Hamid Reza Ghasemibasir,
Resident of Pathology
6. Ali-Reza Mesbah,
Resident of Pathology,
1-6: Isfahan University of Medical Science,
Isfahan – Iran.
Correspondence
Mohammad Ali Rajabi
E-mail: rajabi32@gmail.com
* Received for Publication: April 17, 2008
* Revision Received: July 15, 2008
* Revision Accepted: July 16, 2008
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