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Volume 25 |
July - September 2009 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Volume 25 |
July - September 2009 |
Number 4 |
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Allopurinol as an adjuvant therapy
for refractory schizophrenia
Arasteh Modabber1, Sanobar Tahaie Najmedin Pharm D2
ABSTRACT
Objective: This study was conducted to investigate the effect of allopurinol in the treatment of chronic refractory schizophrenia.
Methodology: This is a double blind cross-over Randomized Clinical Trial. Nineteen schizophrenic cases in two groups is quite a low number to arrive at meaningful conclusion. Patients were grouped in allopurinol and placebo group by randomized blocking method. The evaluation of symptoms was done by Positive and Negative Syndrome Scale (PANSS) questionnaire at 0, 3, 6, 9 and 12 months and one year after the cessation of drug consumption. The data was analyzed by paired T test and Mann-Whitney U test.
Results: There was a significant decrease in positive, general and total symptoms’ scores in patients who took allopurinol for first six month in comparison to their baseline score at beginning of the study (P<0.05). Finally, positive, negative, general and total score had no significant difference between allopurinol and placebo treatment (P>0.05).
Conclusion: Our study shows some degree of decrease (but not significant) in symptoms scores. It seems that more studies with a larger sample size, different doses of allopurinol and different group of patients are necessary in high refractory schizophrenic patients to come at some meaningful conclusions.
KEY WORDS: Chronic schizophrenia, Allopurinol, Adenosine.
Pak J Med Sci July - September 2009 Vol. 25 No. 4 591-596
How to cite this article:
Modabber A, Pharm STND. Allopurinol as an adjuvant therapy for refractory schizophrenia. Pak J Med Sci 2009;25(4):591-596.
1. Arasteh Modabber MD,
Assistant Professor of Psychiatry Department,
Kurdistan University of Medical Sciences,
Pasdaran Str,
Psychiatry Hospital,
Sanandaj, Iran.
2. Sanobar Tahaie Najmedin,
Pharmacist,
Faculty of Medicine,
Kurdistan University of Medical Sciences,
Sanandaj, Iran.
Correspondence
Arasteh Modabber,
Email: m_araste2007@yahoo.com
* Received for Publication: October 14, 2008
* Revision Received: October 21, 2008
* 2nd Revision Received: June 11, 2009
* Final Revision Accepted: June 21, 2009
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