Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 25

July - September 2009

Number  4


 

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Total antioxidant status in women
with breast cancer

Isam Hamo Mahmood1, Kassim Salih Abdullah2, Mohammed Salih Abdullah3

ABSTRACT

Objective: To measure the concentration of total antioxidant status (TAS) in women with breast cancer.

Methodology: This is a case control study conducted in Al-Salam Hospital and Department of Pharmacology in Mosul Medical College. Twenty women having histologically confirmed breast cancer and twenty age-matched healthy volunteer women participated in the study. Serum total antioxidant status (TAS) was measured in both groups.

Results: Mean TAS of the patient group (0.910.32 mmol/l) was significantly lower (P<0.001) than that of the control group (1.820.14 mmol/l).

Conclusion: The present study demonstrated that women with breast cancer have a low level of TAS as compared to those of healthy women. It further emphasizes the growing concern that oxidative damage may occur in those patients that exhaust the antioxidant defense of the body leading to a low levels of TAS. Administration of antioxidant supplements such as a combination of vitamins A, C and E are necessary in women at high risk of developing breast cancer or after surgery or with anticancer drugs.

KEY WORDS: Oxidative stress, Antioxidants, Breast cancer.

Pak J Med Sci    July - September 2009    Vol. 25 No. 4    609-612

How to cite this article:

Mahmood IH, Abdullah KS, Abdullah MS. Total antioxidant status in women with breast cancer. Pak J Med Sci 2009;25(4):609-612.


1. Isam Hamo Mahmood, PhD,
2. Kassim Salih Abdullah, PhD,
1-2: Department of Pharmacology,
College of Medicine, Mosul, Iraq.
3. Mohammed Salih Abdullah,
Arabic Board in Surgery,
Surgeon in Al-Salam Hospital, Mosul, Iraq.

Correspondence

Isam Hamo Mahmood,
Assistant Professor, Dept. of Pharmacology,
College of Medicine, Mosul, Iraq.
Email: isam_mahmood@yahoo.com

* Received for Publication: January 27, 2009
* Revision Received: May 29, 2009
* Revision Accepted: June 1, 2009



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