Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 25

July - September 2009

Number 4


 

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Thyroid function in mothers who gave birth to
neonates with transient congenital hypothyroidism

Gholamreza Asadi Karam1, Hamid Hakimi2, Mohsen Rezaeian3,
Abdollah Gafarzadeh4, Hamidreza Rashidinejad5, Mohammad Khaksari6

ABSTRACT

Objective: To determine the thyroid status of motherís of newborns with primary congenital hypothyroidism.

Methodology: Thyroid function tests were carried out on 80 mothers of hypothyroid newborns and 80 mothers of non-hypothyroid newborns as control.

Results: The mean difference of the tests revealed that mothers of congenitally hypothyroid infants had a lower triiodothyronine resin uptake (T3RU) concentrations compared with the control population. The higher value of free thyroxin index (FTI) in case group showed a tendency to significance. The proportional frequency distribution showed; T3RU and triiodothyronine (T3) had a significant difference, and FTI showed a tendency to significance. There were no significant differences between; thyroid-stimulating hormone (TSH), thyroxine (T4) and anti-thyroid peroxidase antibodies (anti-TPO) in two groups.

Conclusions: These results indicated that at least some cases of primary congenital hypothyroidism were attributable to the maternal thyroid disease. Therefore, we recommend that each pregnant woman should be assessed for thyroid function in region with a high prevalence of thyroid disease.

KEY WORDS: Congenital hypothyroidism, Thyroid function tests, Anti-thyroid peroxidase antibodies, Motherís thyroid status.

Pak J Med Sci    July - September 2009    Vol. 25 No. 4    568-572

How to cite this article:

Karam GA, Hakimi H, Rezaeian M, Gafarzadeh A, Rashidinejad H, Khaksari M. Thyroid function in mothers who gave birth to neonates with transient congenital hypothyroidism. Pak J Med Sci 2009;25(4):568-572.


1. Gholamreza Asadi Karam,
Dept of Biochemistry,
2. Hamid Hakimi,
Dept of Parasitology & Immunology,
3. Mohsen Rezaeian,
Dept of Epidemiology,
4. Abdollah Gafarzadeh,
Dept of Parasitology & Immunology
5. Hamidreza Rashidinejad,
Dept of Internal Medicine,
6. Mohammad Khaksari,
Dept of Physiology,
1-4: Rafsanjan Medical University,
Faculty of Medicine,
Rafsanjan, Iran.
5-6: Kerman University of Medical Sciences,
Kerman, Iran.

Correspondence:

Gholamreza Asadi Karam,
Dept of Biochemistry, Faculty of Medicine,
Rafsanjan Medical University,
Post Code; 7719617996
Rafsanjan Ė Iran.
E-mail: asadi_ka@yahoo.com 

* Received for Publication: May 24, 2008
* Revision Received: January 19, 2009
* Revision Accepted: June 5, 2009



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