Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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CASE REPORT

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Volume 25

July - September 2009

Number  4


 

Abstract
PDF of this Article

A report of three cases with thrombotic thrombocytopenic
purpura (TTP) secondary to an Occult gastric adenocarcinoma

Mohammad Forat Yazdi1, Zahra Hashemian2,
Hossein Nazmieh3, Hamidreza Ghadimi4

ABSTRACT

Thrombotic thrombocytopenic purpura (TTP) is a disseminated form of thrombotic microangiopathy with clinical findings consisting of fever, microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fluctuating neurologic impairment and renal dysfunction. However, Microangiopathic hemolytic anemia has been described in association with disseminated malignancies, most commonly adenocarcinoma of the breast or stomach. We present three patients with microangiopathic anemia in whom metastatic cancer was finally diagnosed; however, they died of refractory hemolytic anemia in the end.

The occurrence of microangiopathic hemolytic anemia and thrombocytopenia in patients with disseminated malignant in gastric adenocarsinoma is well documented. Therefore, the diagnosis of tumor-associated TTP should be considered in unresponsive TTP patient treated with plasmapheresis.

KEY WORDS: Thrombotic thrombocytopenic purpura, Gastric carcinoma, Microangiopathic hemolytic anemia.

Pak J Med Sci    July - September 2009    Vol. 25 No. 4    689-692

How to cite this article:

Forat Yazdi M, Hashemian Z, Nazmieh H, Ghadimi HR. A report of three cases with Thrombotic Thrombocytopenic Purpura (TTP) secondary to an Occult gastric adenocarcinoma. Pak J Med Sci 2009;25(4):689-692.


1- Mohammad Forat Yazdi, MD,
Assistant professor of Internal Medicine (Oncologist)
2- Zahra Hashemian, MD,
General practitioner (RDC Researcher)
3- Hossein Nazmieh, MSc
MS in nursing
4- Hamidreza Ghadimi, MD,
General practitioner
1-4: Dept. of Oncology,
Shaheed Sadoughi University,
Yazd Iran.

Correspondence

Zahra Hashemian, MD
RDC Center Building
Safaieh. Yazd Iran.
E-mail: zhashemian@yahoo.com

* Received for publication: February 20, 2009
* Revision Received June 30, 2009
* 2nd Revision Received: July 11, 2009
* Final Revision Accepted: July 13, 2009



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