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Volume 26 |
July - September 2010 |
Number 3 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ORIGINAL ARTICLE |
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Volume 26 |
July - September 2010 |
Number 3 |
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Serum Copper concentration in Neural Tube
Defects pregnancies in Gorgan-Northern Iran:
A case control studyMohammad Jafar Golalipour1, Azad Reza Mansourian2, Abbas Ali Keshtkar3
ABSTRACT
Objectives: To determine an association between copper deficiency and neural tube defects in Northern Iran, which is reported to have a high prevalence of neural tube defects.
Methodology: This hospital based case control study was conducted on 13 mothers with newborns having neural tube defects and 35 healthy controls mothers in Northern Iran during 2005-2006. Serum copper was measured by spectrophotometery.
Results: Serum copper level in mothers with NTD affected newborns and mothers with normal newborns was 15.9±6.1 micromol/litter and 15.2±6.2 micromol/litter, respectively. Overall 15.4% of mothers in case group and 25.7 % of mothers in control group had copper deficiency. Logistic regression analysis showed no association between the presence of NTD and copper deficiency (OR =0.5, 95% Cl: 0.05-3.2).
Conclusion: This study showed that there is no association between the presence of neural tube defects (NTD) and copper deficiency.
KEY WORDS:
Birth Defect, Neural tube defects, Anencephaly, Copper deficiency, Pregnancy.Pak J Med Sci July - September 2010 Vol. 26 No. 3 585-588
How to cite this article:
Golalipour MJ, Mansourian AR, Keshtkar AA. Serum Copper concentration in Neural Tube Defects pregnancies in Gorgan-Northern Iran: A case control study. Pak J Med Sci 2010;26(3):585-588
1. Mohammad Jafar Golalipour, PhD
Professor,
Department of Embryology,
Gorgan Congenital Malformations Research Center.
2. Azad Reza Mansourian, PhD
Associate Professor,
Department of Biochemistry.
3. Abbas Ali Keshtkar, MD, PhD
Assistant Professor,
Department of Social Medicine.
1-3: Golestan University of Medical Sciences,
Gorgan, Iran.
Correspondence:
Dr. Mohammad Jafar Golalipour
Gorgan Congenital Malformations Research Center,
Golestan University of Medical Sciences,
Gorgan, Iran.
P.O. Box: 49175-553.
E-mail: mjgolalipour@yahoo.com
* Received for Publication: December 17, 2009
* Accepted: April 6, 2010
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