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ORIGINAL ARTICLE |
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Volume 21 |
October December 2005 |
Number 4 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 21 |
October December 2005 |
Number 4 |
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Therapeutic Effects of Restricted Diet in Obese
Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
Sh. Ravanshad, B. Amirkalali, M. Saberfirozi,
N. Zare & E. Setoudeh Maram
Abstract:
Objective: In this study, the effect of restricted diet in obese patients with Non-Alcoholic Fatty Liver Disease (NAFLD) was evaluated.
Design: A convenient, clinical trials study (before and after) with 6 weeks treatment period.
Subjects: Forty NAFLD patients (15 men and 25 women) with mean age 45.8±7.6 years were selected among the patient referred to gastroenterology clinic of Motahary Center.
Setting: Patients selection was based on BMI > 25 kg/m2 and NAFLD patient. Anthropometric indices were measured and BMI was calculated. A food frequency questionnaire was collected before and after consumption of diet containing 12-15% protein, 25-30% fat and 55-60% carbohydrate. A fasting blood sample for measuring LFT were collected at the beginning and after 6 weeks consumption of low fat and low calorie diet.
Result: There were statistically significant decrease in mean body weight (p<0.001) and BMI (p<0.001) after 6 weeks consumption of low fat, low caloric diet. Mean serum Alkaline Phosphatase (p<0.05), ALT (p<0.05), AST (p<0.01) and direct bilirubin (p<0.01) were significantly decreased after 6 weeks consumption of restricted diet. Mean Serum Total Cholesterol (p<0.05), LDLc (p<0.001) and FBS (p<0.05) decreased but mean HDLc and serum globulin were significantly (p<0.001) increased after 6 weeks dietary restriction.
Conclusions: These findings suggest that consumption of low fat, low caloric diet for 6 weeks in obese patient with NAFLD have a positive effect on body weight, BMI and it improves blood glucose lipids and LFT profile.
Key words: Diet Therapy, Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity
Pak J Med Sci October-December 2005 Vol. 21 No. 4 472-475
Correspondence:
Dr. Sh. Ravanshad
Shiraz Univesity of Medical Sciences
P.O. Box: 71345 / 1711,
Shiraz, IRAN
E-mail: setodeha@sums.ac.ir
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