Pakistan Journal of Medical Sciences

Published by : PROFESSIONAL MEDICAL PUBLICATIONS

ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 22

October - December 2006

Number 4


 

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Serum uric acid correlates with the progression of
nephropathy in patients with diabetes mellitus

Emeka A Nwankwo1, William W Wudiri2, Amos A Gadzama3

ABSTRACT

Background: The heavy burden of end stage renal disease has made primary and secondary measures to prevent the development or progression of chronic kidney disease a priority. Search for markers of progression as in this study is necessitated by the fact that progression of kidney disease is multifactorial and for there to be some meaningful impact on the outcome all of the pathogenetic mechanisms will need to be identified and blocked.

Methods: We studied the hospital records of the diabetic patients with impaired renal function on presentation and who had a minimum period of follow up of 12 months. We sought any correlation between the progression of kidney disease (as measured by the reciprocal of serum creatinine against time) and known cardiovascular disease risk factors such as age, gender, smoking, cholesterol and proteinuria and serum uric acid.

Results: Fifty-five (35 male and 20 female) diabetic patients with a mean age of 64.910.4 years and a mean follow up period of 20 months were studied. The slope of the reciprocal of serum creatinine for the study population was -0.005310.000354dL/mg/ month. We observed a significant correlation between the slope of the reciprocal of serum creatinine and serum uric acid for the total study population (r = 0.272, p = 0.044) and male but not the female (male r = -0.335, p=0.049, female r = -0.128, p = 0.590).

Conclusion: In a cohort of diabetics with impaired renal function at presentation attaining satisfactory control of blood pressure, blood sugar and lipids, the serum uric acid correlates with the progression of the nephropathy.

KEYWORDS: Progression, nephropathy, diabetes, uric acid.

Pak J Med Sci October - December 2006 Vol. 22 No. 4 391-395


1. Dr. Emeka A. Nwankwo B.Med.Sc, MB.BS, FMCP,
Department of Medicine

2. William W Wudiri MB.BS, FMCP, M.Med Sc (Sheffield)
Kidney Centre,

3. Amos A Gadzama MB.BS, FWACP
Department of Chemical Pathology

1-3: University of Maiduguri,
Teaching Hospital,
PMB 1069 Maiduguri, Nigeria.

Correspondence:
Dr. EA Nwankwo
E-Mail: eanwankwo@yahoo.com

* Received for Publication: October 14, 2005

* Accepted: June 20, 2006


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