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Volume 22 |
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Number 4 |
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Volume 22 |
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Chemokines and their association
with Paediatric DiseasesFahad Abdullah Al-Zamil1
ABSTRACT
The knowledge about chemokines and their receptors activity is an essential need of health care professionals. Chemokines represent a superfamily of small, inducible, secreted, proinflammatory cytokines involved in a variety of function in leukocyte trafficking, recruiting, and recirculation. The purpose of this review is together and highlights the different studies concerning with chemokines and their potential effects with various diseases. Chemokines play a significant role in many pathophysiological processes such as inflammation, allergic responses, autoimmune diseases, angiogenesis and tumor growth. In addition, particular chemokines have been reported to act on hematopoietic progenitor cells, influence wound healing and have a close assoiciation between their receptors and certain human diseases. It is important to know the biological characteristics of chemokines and their receptors activity. It has been also observed that there is a close assoiciation between chemokines, chemokine receptors, cells and certain adult and paediatric diseases. In additon, chemokines play a significant role in many pathophysiological processes such as inflammation, infectious, allergic response and autoimmune diseases.
For this review we reviewed English-language MEDLINE publications from 1966 through January 2006 for experimental, observational and clinical studies having relation with chemokines with different diseases. Approximately 72 publications were reviewed based on the relevance, strength and quality of design and methods, 54 publications were selected for inclusion.
KEY WORDS: Chemokines, classification of chemokines, chemokine receptors, peadiatric diseases.
Pak J Med Sci October - December 2006 Vol. 22 No. 4 496-502
1. Dr. Fahad Abdullah Al-Zamil MBBS, ABP
Department of Paediatrics,
College of Medicine, King Khalid University Hospital,
King Saud University, Riyadh, Saudi Arabia.Correspondences:
Dr. Fahad Abdullah Al Zamil,
Associate Professor,
Department of Paeditrics (39),
College of Medicine,
King Khalid University Hospital,
P.O. Box 2925, Riyadh 11461.
Kingdom of Saudi Arabia
E-Mail: fahad_alzamil@hotmail.com* Received for Publication: May 11, 2006
* Accepted: June 30, 2006
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