|
|
||||
|
Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
||||
|
ISSN 1681-715X |
||||
|
||||
|
- |
||||
|
ORIGINAL ARTICLE |
||||
|
- |
||||
|
Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
||
|
|
||||
|
||||
|
|
||||
|
Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
||||
|
ISSN 1681-715X |
||||
|
||||
|
- |
||||
|
ORIGINAL ARTICLE |
||||
|
- |
||||
|
Volume 23 |
October - December 2007 (Part-I) |
Number 5 |
||
|
|
||||
|
||||
Effect of simvastatin on insulin sensitivity
in type 2 diabetic subjects
M. Zafar Iqbal Hydrie1, Rashida Qasim2,
M. Yakoob Ahmadani3,
Zahid Miyan4, Asher Fawwad5, Abdul Basit6
ABSTRACT
Objective: To study the effect of Simvastatin therapy on insulin sensitivity in type 2 Diabetes mellitus subjects.
Methodology: This is a randomized case control study, conducted at Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan. The study was conducted in 100 type 2 diabetes subjects of both sexes. Patients were randomized into two groups. Fifty patients were given Simvastatin 40mg/day for three months while 50 patients were used as controls. Both groups had similar anthropometric (age, duration of diabetes, BMI and Blood pressure) and biochemical (serum creatinine, fasting plasma glucose, fasting insulin level and lipid profile) characteristics. Insulin resistance was assessed by calculating homeostasis model assessment for insulin resistance (HOMA-IR) before and after 3 months of simvastatin treatment (40mg/day).
Results: Simvastatin (40mg/day) markedly decreased cholesterol, triglycerides and LDL levels but did not significantly affect insulin sensitivity as determined by HOMA-IR. However it improved insulin sensitivity in subjects having insulin resistance. (HOMA IR reduction 1.92; p=0.001)
Conclusion: Short term simvastatin therapy (3 months) had no effect on insulin sensitivity, but had a significant lipid lowering effect in all the subjects.
KEY WORDS: Diabetes, Insulin sensitivity, Lipid profile, Simvastatin.
Pak J Med Sci October - December 2007 (Part-I) Vol. 23 No. 5 755-759
1. Dr. M. Zafar Iqbal Hydrie, M Phil,
Research Officer, Research Department,
2. Prof. Rashida Qasim, PhD
Chairperson, Z.A School of Medical Technology,
Sindh Institute of Urology & Transplantation,
Karachi - Pakistan.
3. Dr Muhammad Yakoob Ahmadani, FCPS
Assistant Professor of Medicine, Dept. of Medicine,
4. Dr Zahid Miyan, MCPS
Senior Registrar,
5. Dr. Asher Fawwad, MPhil,
Research Officer, Research Department,
6. Prof. Abdul Basit, FRCP
Professor of Medicine, Head of Department,
Medical Unit - IV, Baqai Medical University, Director,
1,6: Baqai Institute of Diabetology and Endocrinology,
Plot 1-2, II-B, Block 2, Nazimabad-2,
Karachi-74600, Pakistan.
Correspondence
Dr. Asher Fawwad, MPhil,
Email: bideresearch@hotmail.com
* Received for Publication: December 6, 2006
* Revision Received: December 27, 2006
* Received Accepted: July 2, 2007
HOME | SEARCH | CURRENT ISSUE | PAST ISSUES
Professional
Medical Publications
Room No. 522, 5th Floor, Panorama Centre
Building No. 2, P.O. Box 8766, Saddar, Karachi - Pakistan.
Phones : 5688791, 5689285 Fax : 5689860
pjms@pjms.com.pk
