Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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Volume 24

October - December 2008 (Part-I)

Number  5
 

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Leptin and Interleukin-6 in
End-Stage Renal Disease

Nasrin Dashti1, Nahid Einollahi2, Fariba Nabatchian3

ABSTRACT

Objective: Leptin, the product of ob gene, is important in control of appetite in humans. The objective was to determine the pre and post serum leptin levels in patients with ESRD (undergoing hemodialysis), to compare the pre serum leptin levels in patients with ESRD and normal healthy controls and to determine the serum IL-6 levels among patients with ESRD before and after hemodialysis.

Methodology: We measured the pre-and post dialysis leptin levels in hemodialysis patients (n=78) with end-stage renal disease (ESRD) with normal volunteers (n=78). Also plasma interleukin-6 was measured pre-and post dialysis in ESRD patients.

Results: Mean serum leptin levels were significantly higher in ESRD patients than in normal control subjects (38.22 ± 6.25 vs. 7.1± 4.38ng/ml, respectively, P<0.01). Serum leptin post-dialysis levels were significantly greater than pre-dialysis levels (44. 78± 5.85 vs. 38.22± 6.25ng/ml, respectively, P<0.05). Post dialysis IL-6 levels was significantly greater than predialysis levels (14.7± 4.6 vs. 9± 4.9pg/ml, respectively, P<0.01).

Conclusion: Kidney contributes to clearance of circulating leptin in humans. However, further studies are needed to evaluate the significance of these elevated leptin levels in patients with end-stage renal disease.

KEYWORD: Leptin, Interleukin-6, ESRD Patients.

Pak J Med Sci    October - December 2008 (Part-I)    Vol. 24 No. 5    694-697

How to cite this article:

Dashti N, Einollahi N, Nabatchian F. Leptin and Interleukin-6 in End-Stage Renal Disease. Pak J Med Sci 2008;24(5):694-97.

1. Nasrin Dashti, Ph.D
2. Nahid Einollahi, Ph.D
3. Fariba Nabatchian, Ph.D
1-3: School of Allied Health Medicine,
Tehran University of Medical Sciences,
Tehran,
Iran.

Correspondence

Nahid Einollahi
E-mail: einolahn@sina.tums.ac.ir

* Received for Publication: October 10, 2007
* Revision Received: June 17, 2008
* Final Revision Accepted: August 22, 2008

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