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Volume 24 |
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Number 5 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 24 |
October - December 2008 (Part-I) |
Number 5 |
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Neuroprotective effects of Aqueous Date Fruit
Extract on focal cerebral ischemia in ratsAsadi Shekaari Majid1, Panahi Marzieh2, Dabiri Shahriar3,
Safi Khani Zahed4, Kalantaripour Taj Pari5ABSTRACT
Objective: Many neuroprotective agents are introduced to protect neurons against oxidative injury. Aqueous Date Fruit Extract (ADFE) is a potent antioxidant agent. This study was designed to investigate neuroprotective effect of ADFE in focal cerebral ischemia in rats.
Methodology: Rats were fed with different doses of ADFE by gastric intubation daily for two weeks. After feeding, right middle cerebral artery was ligated for 30 minutes followed by 48 reperfusion. Then animals were sacrificed and brains removed for Nissl staining. Neuronal damage was then estimated in three distinct areas of CA1 of hippocampus subfield. After determination of ADFE optimal dose, immunohistochemistry was performed for p53 expression.
Results: The optimal dose of ADFE significantly inhibited neuronal damage induced by cerebral ischemia.
Conclusion: The results may suggest that the effectiveness of ADFE in focal cerebral ischemia is most probably due to its antioxidant property.
KEYWORDS: Neuroprotection, Date fruit extract, Ischemia, CA1, Hippocampus.
Pak J Med Sci October - December 2008 (Part-I) Vol. 24 No. 5 661-665
How to cite this article:
Majid AS, Marzieh P, Shahriar D, Zahed SK, Pari KT. Neuroprotective effects of Aqueous Date Fruit Extract on focal cerebral ischemia in rats. Pak J Med Sci 2008;24(5):661-65.
1. Panahi Marzieh, Ph.D,
Assisstant professor of Histology,
Ahwaz Jondi Shapour Medical University, Ahwaz, Iran.
2. Asadi Shekaari Majid, Ph.D
Student of Histology, Acadmic Staff of Kerman
Neuroscience Research Center, Kerman, Iran.
3. Dabiri Shahriar, MD,
Professor of Pathology,
Kerman Medical University, Kerman, Iran.
4. Safi Khani Zahed Ph.D.
Associate Prof. of Anatomy,
Jondi Shahpour Medical University, Ahwaz - Iran.
5. Kalantaripour Taj Pari MS.c,
Academic Staff of Midwifery & Nursing Faculty,
Kerman Azad University, Kerman - Iran.
Correspondence
Panahi Marzieh,
No :18, West Kashan St.,
Golestan Bulvar, Ahwaz, Iran
E-mail: marzpanah@yahoo.com
* Received for Publication: March 4, 2008
* Accepted: July 22, 2008
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