Pakistan Journal of Medical Sciences

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ORIGINAL ARTICLE

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Volume 24

October - December 2008 (Part-I)

Number  5


 

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Antioxidants, Oxidative Stress status and
Waist/Hip ratio in normolipidaemic
AMI patients

Arun Kumar1, Ramiah Sivakanesan2, Susil Gunasekera3

ABSTRACT

Objectives: The main objectives were to compare antioxidants and lipid peroxidation markers in normolipidaemic AMI patients to age/sex-matched controls.

Methodology: The study was conducted in Hindustan Institute of Medical Sciences and Research, Sharda Hospital, India on 165 AMI patients, (123 males and 42 females) admitted in ICCU, Sharda Hospital with age/sex-matched 165 controls (123 males and 42 females). Apart lipid profile measurement, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase were determined. Oxidative stress markers, malondialdehyde (MDA) and conjugated diene (CD) were also determined.

Results: The mean SOD activity in patients were 813.9 (U/gHb) compared to 1826.5 (U/gHb) in controls which was significantly lower (p<0.02). The mean GPx activity in patients was 42.6 (U/gHb) significantly lower than controls (p<0.001), 61.3 (U/gHb). Significant changes (p<0.001) were observed in mean catalase activities in patients, 193.06 (k/gHb) compared to control 256.2 (k/gHb).The mean MDA levels were significantly higher in patients (p<0.02) showing 14.81 (nmol/L), compared to control, 5.71 (nmol/L). Similarly conjugated diene levels in patients were higher, 48.28 (Ámol/L) than controls 31.0 (Ámol/L) (p<0.001).

Conclusions: Myocardial Infarction is a multifactorial disease in which normolipidaemic subjects could also be a victim even though the risk is higher in dyslipidemic subjects. Apart from lipid profile measurement in health check up package, inclusion of antioxidants studies should also be incorporated as the current studies highlight the facts with special attention to higher waist/ hip ratio subjects.

KEY WORDS: Antioxidants, Malondialdehyde, Conjugated diene, AMI, Waist / Hip ratio, Normolipidemia.

Pak J Med Sci    October - December 2008 (Part-I)    Vol. 24 No. 5    689-693

How to cite this article:

Kumar A, Sivakanesan R, Gunasekera S. Antioxidants, Oxidative Stress status waist/hip ratio in normolipidaemic AMI patients. Pak J Med Sci 2008;24(5):689-93.


1. Arun Kumar,
Research Scholar,
Department of Biochemistry,
Faculty of Medicine,
University of Peradeniya,
Sri Lanka.
2. Prof. Ramiah Sivakanesan
Head, Department of Biochemistry,
Faculty of Medicine,
University of Peradeniya,
Sri Lanka.
3. Dr. Susil Gunasekera,
Senior Lecturer,
Department of Biochemistry,
Faculty of Medicine, University of Peradeniya,
Sri Lanka.

Correspondence

Dr. Arun Kumar,
Assistant Professor,
Phullari Campus,
Department of Biochemistry,
Manipal College of Medical Sciences,
Pokhara,
Nepal.
Email: arun732003@gmail.com

* Received for Publication: October 22, 2008
* Revision Received: February 13, 2008
* 2nd Revision Received: August 25, 2008
* Final Revision Accepted: August 26, 2008



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