Pakistan Journal of Medical Sciences

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ISSN 1681-715X

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ORIGINAL ARTICLE

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Volume 25

October - December 2009 (Part-I)

Number  5


 

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Cytarabin and daunorubicin or idarubicin in
induction therapy of Acute Myeloid Leukemia patients

Jamal Eivazi-Ziaei1, Iraj Asvadi Kermani2, Alireza Nikanfar3, Hadi Maljaie4,
Ali Mahmoudpour5, Roya Dolatkhah6, Mehri Golchin7, Jalil Vaez8

ABSTRACT

Objectives: Acute myeloid leukemia (AML), the most common form of acute leukemia, is treated by remission induction and post-remission therapy. Remission induction is usually achieved by administration of cytarabine along with an anthracycline such as Daunorubicin (DAU) or Idarubicin (IDA). Our objective was see the benefits if any of IDA over DAU in AML therapy.

Methodology: Eighty adult AML patients were enrolled in this study, where 40 received DAU and 40 were treated with IDA. Remission status in each subject was studied and response to therapy was subsequently analyzed using SPSS.

Results: Complete remission, partial remission and no responsive status were 15, 19, and 14 respectively for patients on DAU and 14, 18, and 11 for patients on IDA protocol. No significant benefit was detected for IDA compared to DAU in response to therapy.

Conclusion: We found no benefit in using IDA over DAU in induction therapy for AML patients treated in northwest of Iran.

Key Words:

Pak J Med Sci    October - December 2009 (Part-I)    Vol. 25 No. 5    829-832

How to cite this article:

Eivazi-Ziaei J, Kermani IA, Nikanfar A, Maljaie H, Mahmoudpour A, Dolatkhah R, et al. Cytarabin and daunorubicin or idarubicin in induction therapy of Acute Myeloid Leukemia patients. Pak J Med Sci 2009;25(5):829-832.


1. Jamal Eivazi-Ziaei,
2. Iraj Asvadi Kermani,
3. Alireza Nikanfar,
4. Hadi Maljaie,
5. Ali Mahmoudpour,
6. Roya Dolatkhah,
7. Mehri Golchin,
8. Jalil Vaez
1-8: Tabriz University Hematology Oncology Research Center,
Shahid Ghazi Ward,
Imam Reza Hospital,
Tabriz, Iran.

Correspondence

Jamal Eivazi-Ziaei
Email: jeziaei@yahoo.com

* Received for Publication: March 3, 2009

* Revision Received: July 15, 2009

* Revision Accepted: July 25, 2009



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