Published by : PROFESSIONAL MEDICAL PUBLICATIONS
|October - December 2007 (Part-II)||
The effect of intramuscular ephedrine in
prevention of hypotension due to propofol
Susan Rasooli1, Masoud Parish2, Ata Mahmoodpoor3,
Farnaz Moslemi4, Sarvin Sanaie5, Sara Faghfuri6
Objective: To evaluate the effect of intramuscular (IM) ephedrine before injection of propofol, to reduce hypotension.
Methodology: It was a prospective, hospital based study conducted during March 2003 to December 2003, at Nikookary Hospital, Tabriz Medical Science University, Iran.
This study was performed on one hundred patients who were candidates for elective ophthalmic surgeries randomized to two groups of 50 patients. In one group (group A) ephedrine 10mg (2cc) and in other group (group B) sterile water 2cc were injected intramuscularly. Twenty minutes before induction of anesthesia or before injection of propofol, during intubation, in 1st, 4th, 7th and 10th minutes of anesthesia blood pressure and heart rate were measured in both groups. The mean values were compared in two groups.
Results: There was only one case with significant mean diastolic blood pressure drop at 1st minute after intubation in group A comparing with group B. P=0.001. In other cases, differences of mean blood pressures were not significant. Also heart rates in all mentioned minutes were significantly higher in group A than group B. P<0.05)
Conclusion: IM injection of ephedrine before induction of anaesthesia with propofol does not have any significant effect in decreasing of patient’s hypotension during operation, however it increases their heart rates. According to the potential hazards of the later complication, especially in old patients, this procedure is not recommended.
KEY WORDS: Propofol, Prophylactic Ephedrine, Intramuscular, Hypotension.
Pak J Med Sci October - December 2007 (Part-II) Vol. 23 No. 6 893-897
1. Susan Rasooli, MD
2. Masoud Parish, MD
1,2: Assistant Professor of Anesthesiology
3. Ata Mahmoodpoor, MD
Anesthesiologist Fellowship of Critical Care Medicine
4. Farnaz Moslemi, MD
Assistant Professor of Anesthesiology
5. Sarvin Sanaie, MD General Physician
6. Sara Faghfuri, MD General Physician
1-6: Department of Anesthesiology and Intensive Care,
Tabriz University of Medical Science,
Tabriz – Iran.
Address: No 423,
Arman Residential Tower, 22nd Bahman Ave.,
Ashrafi Isfahani Highway,
Tehran – Iran.
* Received for Publication: April 18, 2007
* Revision Accepted: August 12, 2007
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